Tie2 kinase inhibitor 2

Cat. No.: HY-113571 Pureza: 99.0%: Ficha de datos
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Tie2 kinase inhibitor 2 (compound 7) is a selective Tie2 kinase inhibitor with an IC₅₀ value of 1 μM. Tie2 kinase inhibitor 2 inhibits endothelial cell tube formation, and can be used for Tie2-mediated angiogenic disorders research.

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Tie2 kinase inhibitor 2 Estructura química

No. CAS : 1020412-97-8

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	Obtener un presupuesto
10 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

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Ver todos los productos específicos de isoformas Tie:

Ver todas las isoformas

Tie1 Tie2

Actividad biológica
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Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target^[1]

Tie2

1 μM (IC₅₀)

Tie2

1.3 μM (IC₅₀)

Peso molecular

529.63

Fòrmula

C₃₁H₃₅N₃O₅

No. CAS

1020412-97-8

Appearance

Solid

Color

White to light brown

SMILES

O=C(C1=CC(C2=CC=C(CN(CC(N[C@H](C3CCCCC3)C)=O)C(OC4=CC=C(C)C=C4)=O)C=C2)=CN=C1)O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (188.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8881 mL	9.4406 mL	18.8811 mL
5 mM	0.3776 mL	1.8881 mL	3.7762 mL
10 mM	0.1888 mL	0.9441 mL	1.8881 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.0%

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Ficha de datos (270 KB) SDS (392 KB)

COA (248 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Jinqi Liu, et al. Identification and characterization of small-molecule inhibitors of Tie2 kinase. FEBS Lett. 2008 Mar 5;582(5):785-91. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8881 mL	9.4406 mL	18.8811 mL	47.2028 mL
	5 mM	0.3776 mL	1.8881 mL	3.7762 mL	9.4406 mL
	10 mM	0.1888 mL	0.9441 mL	1.8881 mL	4.7203 mL
	15 mM	0.1259 mL	0.6294 mL	1.2587 mL	3.1469 mL
	20 mM	0.0944 mL	0.4720 mL	0.9441 mL	2.3601 mL
	25 mM	0.0755 mL	0.3776 mL	0.7552 mL	1.8881 mL
	30 mM	0.0629 mL	0.3147 mL	0.6294 mL	1.5734 mL
	40 mM	0.0472 mL	0.2360 mL	0.4720 mL	1.1801 mL
	50 mM	0.0378 mL	0.1888 mL	0.3776 mL	0.9441 mL
	60 mM	0.0315 mL	0.1573 mL	0.3147 mL	0.7867 mL
	80 mM	0.0236 mL	0.1180 mL	0.2360 mL	0.5900 mL
	100 mM	0.0189 mL	0.0944 mL	0.1888 mL	0.4720 mL