TIS108

Cat. No.: HY-136403 Purity: 99.92%: Data Sheet
COA

SDS
Handling Instructions
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TIS108 is a triazole-type strigolactone biosynthesis inhibitor. TIS108 inhibits Arabidopsis embryogenesis and root hair growth, and promotes shoot branching. TIS108 can also increase the gibberellin content in Gastrodia elata. TIS108 can be used in the research of plant growth and development as well as plant responses to the environment.

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TIS108 화학구조

CAS No. : 1315459-30-3

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Brassinolide Gibberellins

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

TIS108 (0-1.6 μM; 0-14 days) can inhibit the number of somatic embryos formed in Arabidopsis explants, partially reverse the up-regulating effect of GR24 (HY-129038) on the expression of ARF5, ARF8, ARF10, and ARF16 genes, and simultaneously affect the expression of WUS and SERK1 genes^[1].
TIS108 (1-3 μM) can increase the number of shoot branches, inhibit root hair elongation, and promote the expression of MAX3 and MAX4 in wild-type Arabidopsis^[2].
TIS108 (10 μM; 14 days) can significantly increase the gibberellin content and reduce the level of GeCYP714A1 in Gastrodia elata tubers^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[3]

Cell Line:	Gastrodia elata tubers
Concentration:	10 μM
Incubation Time:	14 days
Result:	Inhibited the level of GeCYP714A1.

분자량

335.40

화학식

C₂₀H₂₁N₃O₂

CAS No.

1315459-30-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)C(N2N=CN=C2)CCCCOC3=CC=CC=C3

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 125 mg/mL (372.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9815 mL	14.9076 mL	29.8151 mL
5 mM	0.5963 mL	2.9815 mL	5.9630 mL
10 mM	0.2982 mL	1.4908 mL	2.9815 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.92%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (246 KB) HNMR (258 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Elhiti M, et al. Synthetic Strigolactone GR24 Improves Arabidopsis Somatic Embryogenesis through Changes in Auxin Responses. Plants (Basel). 2021 Dec 10;10(12):2720. [Content Brief]

[2]. Ito S, et al. Effects of strigolactone-biosynthesis inhibitor TIS108 on Arabidopsis. Plant Signal Behav. 2013 May;8(5):e24193. [Content Brief]

[3]. Zhang YX, et al. [Influence of Tis108 on GA content and expression of key enzyme GeCYP714A1 involved in GA deactivation of Gastrodia elata]. Zhongguo Zhong Yao Za Zhi. 2024 Aug;49(15):4007-4014. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9815 mL	14.9076 mL	29.8151 mL	74.5379 mL
	5 mM	0.5963 mL	2.9815 mL	5.9630 mL	14.9076 mL
	10 mM	0.2982 mL	1.4908 mL	2.9815 mL	7.4538 mL
	15 mM	0.1988 mL	0.9938 mL	1.9877 mL	4.9692 mL
	20 mM	0.1491 mL	0.7454 mL	1.4908 mL	3.7269 mL
	25 mM	0.1193 mL	0.5963 mL	1.1926 mL	2.9815 mL
	30 mM	0.0994 mL	0.4969 mL	0.9938 mL	2.4846 mL
	40 mM	0.0745 mL	0.3727 mL	0.7454 mL	1.8634 mL
	50 mM	0.0596 mL	0.2982 mL	0.5963 mL	1.4908 mL
	60 mM	0.0497 mL	0.2485 mL	0.4969 mL	1.2423 mL
	80 mM	0.0373 mL	0.1863 mL	0.3727 mL	0.9317 mL
	100 mM	0.0298 mL	0.1491 mL	0.2982 mL	0.7454 mL

TIS108 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIS1081315459-30-3TIS 108TIS-108Phytohormonestrigolactoneembryogenesisepi-5DSGastrodia elataArabidopsisInhibitorinhibitorinhibit

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TIS108

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