2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. TOP5300

TOP5300 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5300 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats.

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TOP5300

TOP5300 Chemical Structure

CAS No. : 1848981-48-5

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TOP5300 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

TOP5300 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5300 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats[1].

In Vivo


Absorption, Distribution, Metabolism and Excretion (ADME) properties of TOP5300[1]

Species Dose (mg/kg) AUCINF_obs (ng·h/mL) t1/2 (h) Cmax (ng/mL) F (%)
Rat 10 2655 5.1 237 20
Mouse 5 5533 2.5 1133 22
Dog 10 8719 391 32

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

570.47

Formule

C28H29Cl2N5O4
CAS No.
SMILES

O=C(N(C(C)(C)C)C)C1=NN(C2=C1COC3=C2C=C(C4=CN(CCO)N=C4)C(OC)=C3)C5=CC(Cl)=CC(Cl)=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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TOP5300 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TOP53001848981-48-5TOP05300TOP 5300TOP-5300TOP 05300TOP-05300Estrogen Receptor/ERRAgonistG-protein coupled receptorFSHRInhibitorinhibitorinhibit

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HY-160856
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