2. Immunology/Inflammation
  3. TREM receptor
  4. TREM2 agonist-4

TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease.

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TREM2 agonist-4

TREM2 agonist-4 構造式

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 423 在庫あり
Solution
10 mM * 1 mL in DMSO USD 423 在庫あり
Solid
5 mg $410 在庫あり
10 mg $615 在庫あり
25 mg $1100 在庫あり
50 mg $1580 在庫あり
100 mg $2290 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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製品説明

TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1].

IC50 & Target[1]

TREM-2

45.9 μM (Kd)

分子量

468.65

分子式

C27H36N2O3S
Appearance

Solid

Color

off-white

SMILES

C=C1CC(C1)C(NC2=CC(C(NC)=O)=CC(C3=C(CCCCCCCC)C=CS3)=C2OC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (213.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1338 mL 10.6689 mL 21.3379 mL
5 mM 0.4268 mL 2.1338 mL 4.2676 mL
10 mM 0.2134 mL 1.0669 mL 2.1338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

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濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1338 mL 10.6689 mL 21.3379 mL 53.3447 mL
5 mM 0.4268 mL 2.1338 mL 4.2676 mL 10.6689 mL
10 mM 0.2134 mL 1.0669 mL 2.1338 mL 5.3345 mL
15 mM 0.1423 mL 0.7113 mL 1.4225 mL 3.5563 mL
20 mM 0.1067 mL 0.5334 mL 1.0669 mL 2.6672 mL
25 mM 0.0854 mL 0.4268 mL 0.8535 mL 2.1338 mL
30 mM 0.0711 mL 0.3556 mL 0.7113 mL 1.7782 mL
40 mM 0.0533 mL 0.2667 mL 0.5334 mL 1.3336 mL
50 mM 0.0427 mL 0.2134 mL 0.4268 mL 1.0669 mL
60 mM 0.0356 mL 0.1778 mL 0.3556 mL 0.8891 mL
80 mM 0.0267 mL 0.1334 mL 0.2667 mL 0.6668 mL
100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.5334 mL
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TREM2 agonist-4 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TREM2 agonist-4TREM receptorTriggering receptors expressed on myeloid cellsHEK293BV2ADInhibitorinhibitorinhibit

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製品名:
TREM2 agonist-4
製品番号:
HY-174378
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