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  3. Drug Derivative
  4. Trimethyl chitosan

Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles.

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Trimethyl chitosan

Trimethyl chitosan Estructura química

No. CAS : 52349-26-5

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Trimethyl chitosan Related Antibodies

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Descripciòn

Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles[1][2].

In Vitro

Trimethyl chitosan (0.05-1.0% (w/v); 2-4 h) reduced transepithelial electrical resistance (TEER) in a concentration-dependent manner in Caco-2 cell monolayer experiments and significantly increased the transmembrane transport efficiency of 14C-mannitol without significantly affecting cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trimethyl chitosan Related Antibodies
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC[C@@H]1[C@@H](C)[C@H](O)[C@@H]([N+](C)(C)C)[C@H](OC)O1.[Cl-].[n]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

H2O : 33.33 mg/mL (ultrasonic and warming and heat to 60°C)

  • Calculadora de molaridad

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL; Clear solution; Need ultrasonic

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

SDS (251 KB)

COA (252 KB)

Instrucciones de manejo (2659 KB)
Referencias
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Trimethyl chitosan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trimethyl chitosan52349-26-5N,N,N-TrimethylchitosanDrug DerivativeDrug derivativedrug deliverynanoparticleswater-solublechitosanInhibitorinhibitorinhibit

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Nombre del producto:
Trimethyl chitosan
Cat. No.:
HY-148033
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