Trontinemab  (Synonyms: RG6102; RO-7126209)

Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1^[1][2][3][4].

IgG1-kappa-(Fab G1-kappa with domain crossover)

Human IgG1 kappa, Isotype Control

Human

APP & TFRC

Trontinemab (0-5 μg/mL, 45 min)-decorated Aβ plaques by Fc receptor-mediated phagocytosis is a major mechanism of Aβ plaque clearance in primary human macrophages^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trontinemab (20 µg/mL) binding to TFR induces first infusion reaction (FIRs) and stimulation of cytokine release via Fc-mediated effector functions in FcgR-humanized mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

101926433  [NCBI] & 7037  [NCBI]

P53601 & P02786

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

194.25 kDa

2568868-35-7

Liquid

Colorless to light yellow

[Trontinemab]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  IgG1-kappa-(Fab G1-kappa with domain crossover)

• 
  Immobilized Human Beta-amyloid/Beta-APP Protein (hFc Tag) can bind Trontinemab. The EC₅₀ for this effect is 34.64 ng/mL.
• 
  Immobilized HY-P71069 TFRC Protein, Human (HEK293, His) can bind Trontinemab. The EC₅₀ for this effect is 193.5 ng/mL.

• [1]. Neațu M, et al. Monoclonal Antibody Therapy in Alzheimer's Disease. Pharmaceutics. 2023 Dec 29;16(1):60.  [Content Brief]

  [2]. Trontinemab. IMGT/mAb-DB.

  [3]. Weber F, et al. Brain Shuttle Antibody for Alzheimer's Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode. Cell Rep. 2018 Jan 2;22(1):149-162.  [Content Brief]

  [4]. Roche H L. Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants with Prodromal or Mild to Moderate Alzheimer’s Disease[J]. ClinicalTrialsgov Identifier: NCT04639050, 2021, 2024.