2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. U-46619

U-46619  (Synonyms: 9,11-Methanoepoxy PGH2)

製品番号: HY-108566 純度: 99.61%
COA 取扱説明書 Technical Support

U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation.

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CAS 番号 : 56985-40-1

容量 価格（税別） 在庫状況 数量
Solvent
1 mg (28.5 mM * 100 μL in Methyl acetate) USD 330 在庫あり
Solvent
5 mg (28.5 mM * 500 μL in Methyl acetate) USD 990 在庫あり
Solvent
10 mg (28.5 mM * 1 mL in Methyl acetate) USD 1585 在庫あり

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カスタマーレビュー

Based on 15 publication(s) in Google Scholar

U-46619 関連抗体

Top Publications Citing Use of Products

    U-46619 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Nov 25;44(11):116505.  [Abstract]

    Adding the RhoA activator U46619 (0.1 μM; 24 h) can partially restore the effect of Wnt5a knockdown on downstream RhoA and Rock1 phosphorylation.

    U-46619 purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 Dec;56(6):228.  [Abstract]

    The expression of autophagy-related proteins in colorectal cancer cells after the addition of the MAPK/ERK pathway activator U-46619 (2 μM) was detected by Western blotting.

    U-46619 purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Oct:240:117107.  [Abstract]

    The summary shows concentration-dependent post-relaxation contraction induced by U46619 (1–1000 nmol/L) in TRPV4fl/fl and TRPV4SMCki/ki mouse aorta.

    U-46619 purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Mar 26:344:119564.  [Abstract]

    Washed human platelets were pretreated with different doses of IsA or solvent in the presence of 1 mM CaCl₂, followed by stimulation with thrombin (0.04 U/mL), collagen (1 μg/mL), and U46619 (0.3 μM). ADP (2 μM)-induced aggregation was performed using platelet-rich plasma.

    U-46619 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Nov 20:225:333-345.  [Abstract]

    U-46619 (0.1 μg/kg). Representative protein blot band.

    Prostaglandin Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    DP EP FP IP TXA2/TP TXB2

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    製品説明

    U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5].

    IC50 & Target

    TXA2/TP

     

    体外実験

    U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1].
    U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1].
    U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1].
    U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    U-46619 関連抗体
    体内実験

    U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 12-15 weeks-old male and female SHR[2]
    Dosage: 5 μg/kg
    Administration: Intravenous injection
    Result: Induceed a significant increase of MABP after 1 min in male SHR.
    分子量

    350.49

    分子式

    C21H34O4
    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    O=C(O)CCC/C=C\C[C@H]1[C@@]2([H])CO[C@@](C2)([H])[C@@H]1/C=C/[C@@H](O)CCCCC
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Solution, -20°C, 2 years
    純度とドキュメンテーション

    純度: 99.61%

    COA (250 KB) HNMR (217 KB) RP-HPLC (242 KB) LCMS (95 KB)

    取扱説明書 (2659 KB)
    参考文献
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    U-46619 Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    U-4661956985-40-19,11-Methanoepoxy PGH2U46619U 46619Prostaglandin ReceptorTXA2plateletsshapechangeaggregationrat cerebrovascular endothelial cellsPC-3 cellInhibitorinhibitorinhibit

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    製品名:
    U-46619
    製品番号:
    HY-108566
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