2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Ubretid

Ubretid  (Synonyms: Distigmine dibromide)

製品番号: HY-119577 純度: 99.0%
COA 取扱説明書 Technical Support

Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder.

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Ubretid

Ubretid 構造式

CAS 番号 : 15876-67-2

容量 価格（税別） 在庫状況 数量
5 mg $73 在庫あり
10 mg $110 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Ubretid 関連抗体

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Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
AChE BChE

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製品説明

Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder[1].

IC50 & Target

AChE

0.25 μM (IC50)

BChE

0.27 μM (IC50)

体外実験

Ubretid inhibits AChE and BChE (IC50s are 0.25 μM and 0.27 μM), increases the level of acetylcholine, activates cholinergic neural pathways, thereby regulating neuronal excitability and synaptic transmission[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ubretid 関連抗体
体内実験

Ubretid (50-100 μg/kg, ip, single dose) increases the efflux level of acetylcholine, results in a decrease in motor activity of rats and induced cholinergic behaviors such as tremor, fasciculation, and tearing[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats models[2]
Dosage: 50-100 μg/kg
Administration: ip, single dose
Result: Increased the level of acetylcholine in the medial prefrontal cortex of rats.
Decreased the motor activity and induced cholinergic behaviors such as tremor, fasciculation, and tearing.
分子量

576.32

分子式

C22H32Br2N4O4
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N(C)CCCCCCN(C)C(OC1=C[N+](C)=CC=C1)=O)OC2=C[N+](C)=CC=C2.[Br-].[Br-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (173.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7351 mL 8.6757 mL 17.3515 mL
5 mM 0.3470 mL 1.7351 mL 3.4703 mL
10 mM 0.1735 mL 0.8676 mL 1.7351 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
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純度とドキュメンテーション

純度: 99.0%

COA (243 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7351 mL 8.6757 mL 17.3515 mL 43.3787 mL
5 mM 0.3470 mL 1.7351 mL 3.4703 mL 8.6757 mL
10 mM 0.1735 mL 0.8676 mL 1.7351 mL 4.3379 mL
15 mM 0.1157 mL 0.5784 mL 1.1568 mL 2.8919 mL
20 mM 0.0868 mL 0.4338 mL 0.8676 mL 2.1689 mL
25 mM 0.0694 mL 0.3470 mL 0.6941 mL 1.7351 mL
30 mM 0.0578 mL 0.2892 mL 0.5784 mL 1.4460 mL
40 mM 0.0434 mL 0.2169 mL 0.4338 mL 1.0845 mL
50 mM 0.0347 mL 0.1735 mL 0.3470 mL 0.8676 mL
60 mM 0.0289 mL 0.1446 mL 0.2892 mL 0.7230 mL
80 mM 0.0217 mL 0.1084 mL 0.2169 mL 0.5422 mL
100 mM 0.0174 mL 0.0868 mL 0.1735 mL 0.4338 mL
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Ubretid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ubretid15876-67-2Distigmine dibromideCholinesterase (ChE)plasma cholinesterasehydrolysissuxamethoniumanticholinesterasepyridostigminedonepezilmyasthenia gravisbladderInhibitorinhibitorinhibit

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Ubretid
製品番号:
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