2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. Xanthine oxidase-IN-22

Xanthine oxidase-IN-22 is an orally active inhibitor of xanthine oxidase (XO) (IC50: 0.0034 μM). Xanthine oxidase-IN-22 exhibits a mixed-type inhibition mode against XO. Xanthine oxidase-IN-22 reduces serum uric acid levels in mice. Xanthine oxidase-IN-22 can be used in research related to hyperuricemia and gout.

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Xanthine oxidase-IN-22

Xanthine oxidase-IN-22 화학구조

CAS No. : 3075445-37-0

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제품 설명

Xanthine oxidase-IN-22 is an orally active inhibitor of xanthine oxidase (XO) (IC50: 0.0034 μM). Xanthine oxidase-IN-22 exhibits a mixed-type inhibition mode against XO. Xanthine oxidase-IN-22 reduces serum uric acid levels in mice. Xanthine oxidase-IN-22 can be used in research related to hyperuricemia and gout[1].

In Vivo

Xanthine oxidase-IN-22 (Compound B33) (5 mg/kg; p.o.; single dose) exhibits significant uric acid-lowering activity in hyperuricemic mice[1].

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Animal Model: Hyperuricemic mice (male, 22-25 g)[1]
Dosage: 5 mg/kg
Administration: p.o.; single dose
Result: Reduced serum uric acid level by 51.9% at 5 h post treatment compared to the model group.
분자량

363.37

화학식

C18H17N7O2
CAS No.
SMILES

CC1=CC(C)=CC(C)=C1NC2=CC(C#N)=NC(N3N=CC(C(O)=O)=C3N)=N2
선적

Room temperature in continental US; may vary elsewhere.
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Keywords:

Xanthine oxidase-IN-223075445-37-0Xanthine OxidaseXOserumuric acidmicehypouricemic agentxanthine oxidaseInhibitorinhibitorinhibit

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Xanthine oxidase-IN-22
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