2. Apoptosis
  3. Ferroptosis
  4. YL-939

YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis.

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YL-939

YL-939 構造式

CAS 番号 : 3023925-68-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 308 在庫あり
Solution
10 mM * 1 mL in DMSO USD 308 在庫あり
Solid
5 mg $280 在庫あり
10 mg $450 在庫あり
25 mg $900 在庫あり
50 mg $1450 在庫あり
100 mg $2350 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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YL-939 関連抗体

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製品説明

YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis[1].

体外実験

YL-939 (0.01-10 μM) efficiently protects cells from ferroptosis with IC50 values of 0.14 μM, 0.25 μM, 0.16 μM, 0.16 μM and 0.24 μM for HT-1080, Miapaca-2, Calu-1, HCT116 and SHSY5Y cells, respectively[1].
YL-939 (5 μM; 10 h; ES-2 cells) reduces the level of ROS in cytosolic, membrane lipids[1].
YL-939 (5 μM; 1-10 h; ES-2 cells) has a biological target of PHB2[1].
YL-939 (3 μM; 10 h; ES-2 cells) improves ferritin protein expression in a concentration-dependent manner and blocks autophagosomes/lysosomes, and hence inhibited ferritinophagy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YL-939 関連抗体

Western Blot Analysis[1]

Cell Line: ES-2 cells
Concentration: 5 μM
Incubation Time: 1, 5, 7.5, and 10 hours
Result: Pulled down PHB2 protein by the probe.

Western Blot Analysis[1]

Cell Line: ES-2 cells
Concentration: 3 μM
Incubation Time: 10 hours
Result: Increased the expression of nuclear receptor coactivator 4 (NCOA4) in a dose-dependent manner.
体内実験

YL-939 (3 mg/kg; i.p.; single injection) ameliorates liver damage in an Acetaminophen (APAP)-induced acute liver injury mode[1]l.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acetaminophen (APAP)-induced male C57BL/6J mouse[1]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; single injection
Result: Inhibited the cell death and inflammatory infiltration in the liver tissues of male C57BL/J6 mice that received APAP.
分子量

426.51

分子式

C25H26N6O
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

C1(C2=CN3C=C(N=C(C3=N2)C4=CCOCC4)C5=CN(N=C5)C6CCNCC6)=CC=CC=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (234.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3446 mL 11.7231 mL 23.4461 mL
5 mM 0.4689 mL 2.3446 mL 4.6892 mL
10 mM 0.2345 mL 1.1723 mL 2.3446 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3446 mL 11.7231 mL 23.4461 mL 58.6153 mL
5 mM 0.4689 mL 2.3446 mL 4.6892 mL 11.7231 mL
10 mM 0.2345 mL 1.1723 mL 2.3446 mL 5.8615 mL
15 mM 0.1563 mL 0.7815 mL 1.5631 mL 3.9077 mL
20 mM 0.1172 mL 0.5862 mL 1.1723 mL 2.9308 mL
25 mM 0.0938 mL 0.4689 mL 0.9378 mL 2.3446 mL
30 mM 0.0782 mL 0.3908 mL 0.7815 mL 1.9538 mL
40 mM 0.0586 mL 0.2931 mL 0.5862 mL 1.4654 mL
50 mM 0.0469 mL 0.2345 mL 0.4689 mL 1.1723 mL
60 mM 0.0391 mL 0.1954 mL 0.3908 mL 0.9769 mL
80 mM 0.0293 mL 0.1465 mL 0.2931 mL 0.7327 mL
100 mM 0.0234 mL 0.1172 mL 0.2345 mL 0.5862 mL
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YL-939 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YL-9393023925-68-7YL939YL 939FerroptosisPHB2ES-2 cellsautophagosomeslysosomesnuclear receptor coactivator 4Inhibitorinhibitorinhibit

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製品名:
YL-939
製品番号:
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