2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Ziconotide

Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Síntesis de péptidos personalizados

Ziconotide

Ziconotide Estructura química

No. CAS : 107452-89-1

Tamaño Stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
250 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Ziconotide:

Other Forms of Ziconotide:

Ziconotide Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Calcium Channel:

Ver todas las isoformas
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research[1].

IC50 & Target[1]

N-type calcium channel

 

Cellular Effect
Cell Line Type Value Description References
PC-12 IC50
0.6 3
Compound: omega-Conotoxin
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx
[PMID: 15537361]
PC-12 IC50
0.5 3
Compound: omega-Conotoxin
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx in the presence of 10 uM nifedipine
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx in the presence of 10 uM nifedipine
[PMID: 15537361]
PC-12 IC50
0.6 3
Compound: omega-Conotoxin
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx
[PMID: 15537361]
PC-12 IC50
0.5 3
Compound: omega-Conotoxin
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx in the presence of 10 uM nifedipine
In vitro antagonism of N-type calcium channels expressed in PC12 cells was determined as the increase in intracellular calcium influx in the presence of 10 uM nifedipine
[PMID: 15537361]
In Vitro

Most native cells express a variety of different calcium channels and as a result, Ziconotide only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1].
Ziconotide delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ziconotide Related Antibodies
In Vivo

Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein[2]
Dosage: 25 pmol/site, 50 pmol/site, 100 pmol/site
Administration: Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
Result: Significantly reduced the mechanical hypersensitivity in animals with EAE.
Peso molecular

2639.13

Fòrmula

C102H172N36O32S7
No. CAS
Sequence Shortening

CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Ziconotide Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziconotide107452-89-1SNX-111SNX111SNX 111Calcium ChannelCa2+ channelsCa channelsnon-opioidanalgesicN-typecalciumchannelssynaptictransmissionintrathecalInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Ziconotide
Cat. No.:
HY-P0062
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.