Ziconotide TFA
Based on 2 publication(s) in Google Scholar
Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research.
For research use only. We do not sell to patients.
- Formula: C116H179F21N36O46S7
- Molecular Weight:3437.30
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ziconotide TFA
MoreAll Calcium Channel Isoforms
More
Biological Activity
|
N-type calcium channel |
Most native cells express a variety of different calcium channels and as a result, Ziconotide TFA only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide TFA also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1].
Ziconotide TFA delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein[2]
-
Dosage:25 pmol/site, 50 pmol/site, 100 pmol/site
-
Administration:Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
-
Result:Significantly reduced the mechanical hypersensitivity in animals with EAE.
Chemical Information
-
Molecular Weight 3437.30
-
Formula C116H179F21N36O46S7
-
Synonyms
SNX-111 TFA
-
Sequence Shortening
CKGKGAKCSRLMYDCCTGSCRSGKC-NH2(Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Br J Pharmacol
Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance. [Abstract]2025 May 13. PMID: 40361281 -
Cell Rep
PCIF1-mediated m6Am modification in ACC neurons participates in inflammatory pain and anxiety. [Abstract]2026 Feb 18;45(3):117016. PMID: 41712381
Purity & Documentation
References
[1]. Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3(1):69-85. [Content Brief]
[2]. Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55(12):9307-9327. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz