1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Ziconotide

Ziconotide 

Cat. No.: HY-P0062
Handling Instructions

Ziconotide is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ziconotide Chemical Structure

Ziconotide Chemical Structure

CAS No. : 107452-89-1

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Description

Ziconotide is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects[1].

IC50 & Target[1]

N-Type Ca2+ Channel

 

Clinical Trial
Molecular Weight

2639.13

Formula

C₁₀₂H₁₇₂N₃₆O₃₂S₇

CAS No.

107452-89-1

Sequence

Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)

Sequence Shortening

CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ZiconotideCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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Ziconotide
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