2. Antibody-drug Conjugate/ADC Related GPCR/G Protein
  3. Peptide-Drug Conjugates (PDCs) GnRH Receptor
  4. Zoptarelin doxorubicin

Zoptarelin doxorubicin  (Synonyms: AEZS-108; AN-152)

Art. -Nr.: HY-16532
SDS
Handling Instructions Technical Support

Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Kundenspezifische Peptidsynthese

Zoptarelin doxorubicin

Zoptarelin doxorubicin Chemische Struktur

CAS. Nr. : 139570-93-7

Größe Preis Verfügbarkeit Menge
1 mg Auf Lager
5 mg Auf Lager
10 mg Auf Lager
50 mg   Angebot einholen  
100 mg   Angebot einholen  

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 Customer Validation

Zoptarelin doxorubicin Related Antibodies

Top Publications Citing Use of Products

  • Biologische Aktivität

  • Reinheit & Dokumentation

  • Verweise

  • Kundenbewertung

Beschreibung

Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1].

IC50 & Target

Apoptosis, LHRH receptors[1]
In Vitro

Zoptarelin doxorubicin (AN-152) inhibits almost 70 % of glioblastoma cell growth, increases almost 250% apoptosis and causes a greater increase in calcein retention[1].
Zoptarelin doxorubicin (AN-152) up-regulates the tumor suppressor and pro-apoptotic p53, and inhibits the expression of the primordial, neuroectodermal stem cell marker, nestin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zoptarelin doxorubicin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 48 h
Result: Brought about an almost 70 % inhibition of tumor cell growth.

Apoptosis Analysis[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 48 h
Result: Increased almost 250 % apoptosis.

Western Blot Analysis[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 24 h
Result: Did not induce any down-regulation of LHRH-R.
Inhibited the expression of the primordial, neuroectodermal stem cell marker, nestin.
Up-regulated the tumor suppressor and pro-apoptotic p53.
In Vivo

Zoptarelin doxorubicin (AN-152) inhibits tumor growth in glioblastoma xenograft mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (injected in the flanks with 1×106 glioblastoma U-87 MG cells)[1]
Dosage: 413 nM/20g
Administration: i.v.; once weekly; for 6 weeks
Result: Significantly inhibited tumor growth compared to the control.
Klinische Studie
Molekulargewicht

1893.01

Formel

C91H117N19O26
CAS. Nr.
Appearance

Solid

Color

Orange to red

Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 50 mg/mL (26.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5283 mL 2.6413 mL 5.2826 mL
5 mM 0.1057 mL 0.5283 mL 1.0565 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5283 mL 2.6413 mL 5.2826 mL 13.2065 mL
5 mM 0.1057 mL 0.5283 mL 1.0565 mL 2.6413 mL
10 mM 0.0528 mL 0.2641 mL 0.5283 mL 1.3206 mL
15 mM 0.0352 mL 0.1761 mL 0.3522 mL 0.8804 mL
20 mM 0.0264 mL 0.1321 mL 0.2641 mL 0.6603 mL
25 mM 0.0211 mL 0.1057 mL 0.2113 mL 0.5283 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Zoptarelin doxorubicin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zoptarelin doxorubicin139570-93-7AEZS-108 AN-152AEZS108AEZS 108AN152AN 152AN-152Peptide-Drug Conjugates (PDCs)GnRH ReceptorGonadotropin releasing hormone receptorGNRHRLHRH receptorsanticancerantitumorglioblastomaU-87 MGInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Online-Anfrage

Your information is safe with us. * Required Fields.

Produktname

  

Requested Quantity *

Name des Antragstellers *

 

Anrede

E-Mail-Addresse *

 

Telefonnummer *

Department

 

Name der Organisation *

City

Bundesland

Country or Region *

      

Bemerkungen

Massenanfrage

Inquiry Information

Produktname:
Zoptarelin doxorubicin
Art. -Nr.:
HY-16532
Menge:
MCE Japan Authorized Agent:

Kundenbewertung

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Produktname

  

Lot #

Name des Antragstellers *

 

E-Mail-Addresse *

Telefonnummer

 

Department *

Name der Organisation *

 

Country or Region *

Bemerkungen

SAFETY DATA SHEET (SDS)

Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.