139570-93-7
Chemical Structure
Zoptarelin doxorubicin
Synonym(s): AEZS-108; AN-152
- CAS No.: 139570-93-7
- Formula:C91H117N19O26
- Molecular Weight:1893.01
IUPAC Name: 2-((2S,4S)-4-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-oxoethyl (3S,6S,9S,12S,15R)-3-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-15-(((S)-1-(((S)-1-((S)-2-((2-amino-2-oxoethyl)carbamoyl)pyrrolidin-1-yl)-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-1,4,7,10,13,21-hexaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,20-hexaazapentacosan-25-oate
InChIKey: OOUACICUAVTCEC-LZHWUUGESA-N
SMILES: OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N)=C1C[C@](O)(C4)C(COC(CCCC(NCCCC[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(NCC(N)=O)=O)=O)=O)=O)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H]7NC(CC7)=O)=O)CC8=CN=CN8)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)CC%11=CC=C(C=C%11)O)=O)=O)=O)=O
Biological Activity: Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1].
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Zoptarelin doxorubicin | Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro. | |||||||||||||||||||||
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Keywords
