2. GPCR/G Protein
  3. GnRH Receptor
  4. Zoptarelin doxorubicin

Zoptarelin doxorubicin  (Synonyms: AEZS-108; AN-152)

Cat. No.: HY-16532
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Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Zoptarelin doxorubicin Chemical Structure

Zoptarelin doxorubicin Chemical Structure

CAS No. : 139570-93-7

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Zoptarelin doxorubicin Related Antibodies

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Description

Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro[1].

IC50 & Target

Apoptosis, LHRH receptors[1]
In Vitro

Zoptarelin doxorubicin (AN-152) inhibits almost 70 % of glioblastoma cell growth, increases almost 250% apoptosis and causes a greater increase in calcein retention[1].
Zoptarelin doxorubicin (AN-152) up-regulates the tumor suppressor and pro-apoptotic p53, and inhibits the expression of the primordial, neuroectodermal stem cell marker, nestin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zoptarelin doxorubicin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 48 h
Result: Brought about an almost 70 % inhibition of tumor cell growth.

Apoptosis Analysis[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 48 h
Result: Increased almost 250 % apoptosis.

Western Blot Analysis[1]

Cell Line: U-87 MG
Concentration: 100 nM
Incubation Time: 24 h
Result: Did not induce any down-regulation of LHRH-R.
Inhibited the expression of the primordial, neuroectodermal stem cell marker, nestin.
Up-regulated the tumor suppressor and pro-apoptotic p53.
In Vivo

Zoptarelin doxorubicin (AN-152) inhibits tumor growth in glioblastoma xenograft mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (injected in the flanks with 1×106 glioblastoma U-87 MG cells)[1]
Dosage: 413 nM/20g
Administration: i.v.; once weekly; for 6 weeks
Result: Significantly inhibited tumor growth compared to the control.
Clinical Trial
Molecular Weight

1893.01

Formula

C91H117N19O26
CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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Zoptarelin doxorubicin Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zoptarelin doxorubicin139570-93-7AEZS-108 AN-152AEZS108AEZS 108AN152AN 152AN-152GnRH ReceptorGonadotropin releasing hormone receptorGNRHRLHRH receptorsanticancerantitumorglioblastomaU-87 MGInhibitorinhibitorinhibit

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