Zoptarelin doxorubicin
Based on 1 Customer Validation
Zoptarelin doxorubicin (AEZS-108; AN-152) is a hybrid anticancer agent, containing Zoptarelin and Doxorubicin. Zoptarelin doxorubicin has been used to research targeting tumors expressing LHRH receptors. Zoptarelin doxorubicin abolishes tumor progression and induces remarkable apoptosis in vitro.
For research use only. We do not sell to patients.
- CAS No.: 139570-93-7
- Formula: C91H117N19O26
- Molecular Weight:1893.01
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Apoptosis, LHRH receptors[1]
Zoptarelin doxorubicin (AN-152) inhibits almost 70 % of glioblastoma cell growth, increases almost 250% apoptosis and causes a greater increase in calcein retention[1].
Zoptarelin doxorubicin (AN-152) up-regulates the tumor suppressor and pro-apoptotic p53, and inhibits the expression of the primordial, neuroectodermal stem cell marker, nestin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U-87 MG
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Concentration:100 nM
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Incubation Time:48 h
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Result:Brought about an almost 70 % inhibition of tumor cell growth.
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Cell Line:U-87 MG
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Concentration:100 nM
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Incubation Time:48 h
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Result:Increased almost 250 % apoptosis.
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Cell Line:U-87 MG
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Concentration:100 nM
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Incubation Time:24 h
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Result:Did not induce any down-regulation of LHRH-R.
Inhibited the expression of the primordial, neuroectodermal stem cell marker, nestin.
Up-regulated the tumor suppressor and pro-apoptotic p53.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nude mice (injected in the flanks with 1×106 glioblastoma U-87 MG cells)[1]
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Dosage:413 nM/20g
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Administration:i.v.; once weekly; for 6 weeks
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Result:Significantly inhibited tumor growth compared to the control.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 139570-93-7
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Appearance Solid
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Molecular Weight 1893.01
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Formula C91H117N19O26
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Color Orange to red
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Synonyms
AEZS-108; AN-152
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 50 mg/mL (26.41 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.5283 mL | 2.6413 mL | 5.2826 mL | 13.2065 mL |
| 5 mM | 0.1057 mL | 0.5283 mL | 1.0565 mL | 2.6413 mL | |
| 10 mM | 0.0528 mL | 0.2641 mL | 0.5283 mL | 1.3206 mL | |
| 15 mM | 0.0352 mL | 0.1761 mL | 0.3522 mL | 0.8804 mL | |
| 20 mM | 0.0264 mL | 0.1321 mL | 0.2641 mL | 0.6603 mL | |
| 25 mM | 0.0211 mL | 0.1057 mL | 0.2113 mL | 0.5283 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Zoptarelin doxorubicin Related Classifications
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