2'-Deoxyguanosine 5'-monophosphate-¹³C₁₀,¹⁵N₅ disodium  (Synonyms: 5′-dGMP-13C10,15N5 disodium)

2'-Deoxyguanosine 5'-monophosphate-¹³C₁₀,¹⁵N₅ (dGMP-¹³C₁₀,¹⁵N₅) disodium is the ¹³C and ¹⁵N labeled 2'-Deoxyguanosine 5'-monophosphate disodium (HY-W013159). 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis^[1][2].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

406.08

¹³C₁₀H₁₂¹⁵N₅Na₂O₇P

33430-61-4

Solid

White to off-white

O[13C@H]1[13CH2][13C@H]([15N]2[13C]([15N]=[13C]([15NH2])[15NH][13C]3=O)=[13C]3[15N]=[13CH]2)O[13C@@H]1[13CH2]OP(O[Na])(O[Na])=O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. M Paula Denofrio, et al. The photosensitizing activity of lumazine using 2'-deoxyguanosine 5'-monophosphate and HeLa cells as targets. Photochem Photobiol Sci. 2009 Nov;8(11):1539-49.  [Content Brief]