2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Others Membrane Transporter/Ion Channel Neuronal Signaling
  3. VD/VDR Drug Metabolite Drug Derivative Calcium Channel
  4. 25,26-Dihydroxyvitamin D3

25,26-Dihydroxyvitamin D3  (Synonyms: 25,26-Dihydroxycholecalciferol)

Cat. No.: HY-15830 Pureté: 95.47%
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25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia.

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25,26-Dihydroxyvitamin D3

25,26-Dihydroxyvitamin D3 Chemical Structure

CAS No. : 29261-12-9

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25,26-Dihydroxyvitamin D3 Related Antibodies

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Description

25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

25,26-Dihydroxyvitamin D3 (intravenous injection) shows no significant anti-rachitic activity in rats; if any such activity exists, it must be lower than 4 IU/μg[2].
25,26-Dihydroxyvitamin D3 (0.25 μg; intravenous injection) does not stimulate bone mineral mobilization in rats fed a low-calcium diet, but it significantly increases intestinal calcium transport, with an activity approximately half that of 25-HCC[2].
25,26-Dihydroxyvitamin D3 (650 pmol; jugular vein injection) induces a significant, rapid, and sustained decrease in serum Ca2+ that lasts for 48 h in vitamin D-deficient, phosphorus-deprived rats[3].
25,26-Dihydroxyvitamin D3 (325 pmol; i.p.; for 5 consecutive days) significantly increases the serum Ca2+ level in vitamin D-deficient rats (p < 0.01)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified strain (maintained on low calcium diet)[2]
Dosage: 0.25 μg
Administration: i.v.; single dose
Result: Elicited no significant elevation of serum calcium concentration (5.1 ± 0.2 mg% vs.
control 4.7 ± 0.1 mg%).
Significantly increased intestinal calcium transport, with a 45Ca serosal/45Ca mucosal ratio of 2.8 ± 0.6 (vs.
control 1.6 ± 0.2).
Was approximately one-half as active as 25-HCC in stimulating intestinal calcium transport.
Animal Model: Sprague-Dawley albino (weanling male; vitamin D deficiency model, fed vitamin D-free diets for 3 weeks)[3]
Dosage: 325 pmol
Administration: i.p.; daily for 5 consecutive days
Result: Increased serum calcium to 6.50 ± 1.75 mg% (p < 0.01 vs.
controls) in normal calcium/phosphorus diet rats.
I
Masse moléculaire

416.64

Formule

C27H44O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]([C@H]1CC[C@@]2([H])/C(CCC[C@]12C)=C/C=C3C(CC[C@H](O)C\3)=C)CCCC(O)(C)CO
Structure Classification
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (240.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4002 mL 12.0008 mL 24.0015 mL
5 mM 0.4800 mL 2.4002 mL 4.8003 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4002 mL 12.0008 mL 24.0015 mL 60.0038 mL
5 mM 0.4800 mL 2.4002 mL 4.8003 mL 12.0008 mL
10 mM 0.2400 mL 1.2001 mL 2.4002 mL 6.0004 mL
15 mM 0.1600 mL 0.8001 mL 1.6001 mL 4.0003 mL
20 mM 0.1200 mL 0.6000 mL 1.2001 mL 3.0002 mL
25 mM 0.0960 mL 0.4800 mL 0.9601 mL 2.4002 mL
30 mM 0.0800 mL 0.4000 mL 0.8001 mL 2.0001 mL
40 mM 0.0600 mL 0.3000 mL 0.6000 mL 1.5001 mL
50 mM 0.0480 mL 0.2400 mL 0.4800 mL 1.2001 mL
60 mM 0.0400 mL 0.2000 mL 0.4000 mL 1.0001 mL
80 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7500 mL
100 mM 0.0240 mL 0.1200 mL 0.2400 mL 0.6000 mL
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25,26-Dihydroxyvitamin D3 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

25,26-Dihydroxyvitamin D329261-12-925,26-DihydroxycholecalciferolVD/VDRDrug MetaboliteDrug DerivativeCalcium ChannelVitamin DVitamin D receptorDrug derivativeCa2+ channelsCa channelsosteomalaciavitamin D-deficient ratsnephrectomized ratsintestinal calcium absorptionintestinal calcium transportserum calciumbone mineralantirachitic activityratsparathyroid hormoneInhibitorinhibitorinhibit

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