3,6-DMAD hydrochloride

Name: 3,6-DMAD hydrochloride
Brand: MedChemExpress
SKU: HY-U00460
Rating: 4.5 (1 reviews)

製品番号: HY-U00460 純度: 99.50%: Data Sheet SDS COA 取扱説明書
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3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

3,6-DMAD hydrochloride 構造式

容量	価格（税別）	在庫状況	数量
5 mg	$210	在庫あり	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of 3,6-DMAD hydrochloride:

3,6-DMAD dihydrochloride お問い合わせ

顧客検証

•Sci Rep. 2026 Mar 21;16(1):14376.

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製品説明

体外実験

3,6-DMAD hydrochloride (0-6 μM; 24 h; RPMI 8226 and MM1.R human MM cells) has cytotoxicity against MM cell lines^[1].
3,6-DMAD hydrochloride (0-30 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits XBP1 splicing (XBP1s) in a dose dependent manner^[1].
3,6-DMAD hydrochloride (0.1-500 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits IRE1α endonuclease activity^[1].
3,6-DMAD hydrochloride (1-60 μM; 2 h; HEK293 cells) inhibits IRE1α oligomerization and IRE1α-GFP foci formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	RPMI 8226 and MM1.R human MM cells
Concentration:	0, 0.5, 1, 2, 3, 4, 5 and 6 μM
Incubation Time:	24 hours
Result:	Inhibited cell survival rate in a dose dependent manner.

Western Blot Analysis^[1]

Cell Line:	HT1080 cells treated with Tg (0.3 μM)
Concentration:	0, 5, 10 and 30 μM
Incubation Time:	14 hours
Result:	Showed XBP1s inhibition at as low as 0.5 μM.

体内実験

3,6-DMAD hydrochloride (10 mg/kg; i.p.; three times every 12 hours, for 84 hours; NOD Scid mice with RPMI 8226 xenograft) has inhibition of XBP1 splicing in vivo^[1].
3,6-DMAD hydrochloride (10 mg/kg; 24 h; i.p.; every 48 hours, for 12 days; NOD Scid mice with RPMI 8226 xenograft) suppresses multiple myeloma xenograft growth in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; three times every 12 hours, for 84 hours
Result:	Inhibited XBP1-luciferase activity in NOD Scid mice with RPMI 8226 xenograft.

Animal Model:	NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; every 48 hours, for 12 days
Result:	Inhibited tumor growth in NOD Scid mice with RPMI 8226 xenograft.

分子式

C₂₂H₃₁N₅

Appearance

Solid

Color

Yellow to brown

SMILES

CN(C1=CC=C2C(N=C3C=C(C=CC3=C2NCCCN(C)C)N(C)C)=C1)C.[x HCl]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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一般には略語で表示されます：C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.50%

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データシート (275 KB) SDS (251 KB)

COA (250 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jiang D, et, al. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 Sep;15(9):2055-65. [Content Brief]

[2]. De SY, et, al. SHP-2 specific deletion in macrophages accelerates pathological cardiac hypertrophy through promoting IRE1α-XBP1s pathway regulated by IL-6 secretion. Research Article. 2022 May 3.