4'-Hydroxy diclofenac-d₄

Name: 4'-Hydroxy diclofenac-d 4
Brand: MedChemExpress
SKU: HY-15550S
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-15550S Reinheit: 98.92%: Data Sheet
COA

SDS
Handling Instructions
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4'-Hydroxy diclofenac-d₄ is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties.

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4'-Hydroxy diclofenac-d₄ Chemische Struktur

CAS. Nr. : 254762-27-1

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Angebot einholen 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Angebot einholen 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solid
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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Other Forms of 4'-Hydroxy diclofenac-d₄:

4'-Hydroxy diclofenac In-stock

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

316.17

Formel

C₁₄H₇D₄Cl₂NO₃

CAS. Nr.

254762-27-1

Unlabeled CAS

64118-84-9

Appearance

Solid

Color

White to light yellow

SMILES

ClC(C=C(C=C1Cl)O)=C1NC2=C(C([2H])=C([2H])C([2H])=C2[2H])CC(O)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMF : ≥ 30 mg/mL (94.89 mM)

Ethanol : ≥ 30 mg/mL (94.89 mM)

DMSO : ≥ 30 mg/mL (94.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1629 mL	15.8143 mL	31.6286 mL
5 mM	0.6326 mL	3.1629 mL	6.3257 mL
10 mM	0.3163 mL	1.5814 mL	3.1629 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.92%

Select Batch:

Data Sheet (276 KB) SDS (420 KB)

COA (253 KB) HNMR (143 KB) RP-HPLC (248 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8. [Content Brief]

[3]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43(3):309-16. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / Ethanol / DMSO	1 mM	3.1629 mL	15.8143 mL	31.6286 mL	79.0714 mL
	5 mM	0.6326 mL	3.1629 mL	6.3257 mL	15.8143 mL
	10 mM	0.3163 mL	1.5814 mL	3.1629 mL	7.9071 mL
	15 mM	0.2109 mL	1.0543 mL	2.1086 mL	5.2714 mL
	20 mM	0.1581 mL	0.7907 mL	1.5814 mL	3.9536 mL
	25 mM	0.1265 mL	0.6326 mL	1.2651 mL	3.1629 mL
	30 mM	0.1054 mL	0.5271 mL	1.0543 mL	2.6357 mL
	40 mM	0.0791 mL	0.3954 mL	0.7907 mL	1.9768 mL
	50 mM	0.0633 mL	0.3163 mL	0.6326 mL	1.5814 mL
	60 mM	0.0527 mL	0.2636 mL	0.5271 mL	1.3179 mL
	80 mM	0.0395 mL	0.1977 mL	0.3954 mL	0.9884 mL