1. Metabolic Enzyme/Protease
  2. Liposome
  3. 4A3-Cit

4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).

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4A3-Cit

4A3-Cit 構造式

CAS 番号 : 2768211-13-6

容量 価格(税別) 在庫状況 数量
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 3415 在庫あり
Solution
10 mM * 1 mL in DMSO USD 3415 在庫あり
Oil
1 mg $500 在庫あり
5 mg $1250 在庫あり
10 mg $1976 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).

体外実験

4A3-Cit can undergo lipid fusion with endosomal membranes within the model, thereby facilitating endosomal escape. 4A3-Cit can enhance the efficiency of in vivo mRNA delivery through Selective Organ Targeting (SORT)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1571.33

分子式

C83H147N3O16S4

CAS 番号
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)C)CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)OCCOC(C(CSCCC(CC/C=C(C)\C)C)C)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (63.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6364 mL 3.1820 mL 6.3640 mL
5 mM 0.1273 mL 0.6364 mL 1.2728 mL
10 mM 0.0636 mL 0.3182 mL 0.6364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます:C1V1 = C2V2

濃度 (開始)

C1

×
体積 (開始)

V1

=
濃度 (終了)

C2

×
体積 (終了)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6364 mL 3.1820 mL 6.3640 mL 15.9101 mL
5 mM 0.1273 mL 0.6364 mL 1.2728 mL 3.1820 mL
10 mM 0.0636 mL 0.3182 mL 0.6364 mL 1.5910 mL
15 mM 0.0424 mL 0.2121 mL 0.4243 mL 1.0607 mL
20 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7955 mL
25 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6364 mL
30 mM 0.0212 mL 0.1061 mL 0.2121 mL 0.5303 mL
40 mM 0.0159 mL 0.0796 mL 0.1591 mL 0.3978 mL
50 mM 0.0127 mL 0.0636 mL 0.1273 mL 0.3182 mL
60 mM 0.0106 mL 0.0530 mL 0.1061 mL 0.2652 mL
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます:C1V1 = C2V2

濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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備考

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Inquiry Information

製品名:
4A3-Cit
製品番号:
HY-153373
数量:
MCE 日本正規代理店: