2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. 6-Me-ATP

6-Me-ATP (N6-Methyl-ATP) is an N6-modified ATP derivative. 6-Me-ATP exhibits excellent binding affinity for GSK3 and acts as a phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptides. 6-Me-ATP is applicable to research related to Alzheimer's disease.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (6-Me-ATP trisodium solution (100 mM)) that retains the same biological activity.

For research use only. We do not sell to patients.

6-Me-ATP

6-Me-ATP Chemical Structure

CAS No. : 3130-39-0

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Other Forms of 6-Me-ATP:

6-Me-ATP Related Antibodies

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Description

6-Me-ATP (N6-Methyl-ATP) is an N6-modified ATP derivative. 6-Me-ATP exhibits excellent binding affinity for GSK3 and acts as a phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptides. 6-Me-ATP is applicable to research related to Alzheimer's disease[1].

In Vitro

6-Me-ATP (10-200 μM; 20 min-2 h) binds 18 distinct human kinases (including GSK3α and GSK3β) from HEK293T cell lysate, with GSK3α exhibiting similar binding affinity to 6-Me-ATP as to native ATP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Me-ATP Related Antibodies
Molecular Weight

521.21

Formula

C11H18N5O13P3
CAS No.
SMILES

CNC1=C2N=CN([C@@H]3O[C@H](COP(O)(OP(OP(O)(O)=O)(O)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6-Me-ATP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Me-ATP3130-39-0N6-Methyl-ATPGSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3human kinasessubstrate peptidesprimed peptide substraterecombinant GST-GSK3βGSK3βHEK293T cell lysatesalzheimer’s diseaseGSK3αInhibitorinhibitorinhibit

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