6-Phosphoglucono-δ-lactone  (Synonyms: 6-PGδL; 6-Phosphonoglucono-D-lactone)

6-Phosphoglucono-δ-lactone (6-PGδL), a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD), is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP). 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research^[1][2][3].

6-Phosphoglucono-δ-lactone is a key metabolic intermediate in the Pentose Phosphate Pathway (PPP)—the core of cellular energy metabolism—and is useful for studying metabolic regulation, oxidative stress, and related diseases (such as cancer and diabetes).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

258.12

C₆H₁₁O₉P

2641-81-8

Solid

White to off-white

O=P(O)(O)OC[C@@H]1[C@H]([C@@H]([C@H](C(O1)=O)O)O)O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Tyson RL, et al. 6-Aminonicotinamide inhibition of the pentose phosphate pathway in rat neocortex. Neuroreport. 2000;11(9):1845-1848.  [Content Brief]

  [2]. Preuss J, et al. Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. J Biomol Screen. 2013;18(3):286-297.  [Content Brief]

  [3]. Morales-Luna L, et al. Glucose-6-Phosphate Dehydrogenase::6-Phosphogluconolactonase from the Parasite Giardia lamblia. A Molecular and Biochemical Perspective of a Fused Enzyme. Microorganisms. 2021 Aug 7;9(8):1678.  [Content Brief]