2641-81-8
Chemical Structure
6-Phosphoglucono-δ-lactone
Synonym(s): 6-PGδL; 6-Phosphonoglucono-D-lactone
- CAS No.: 2641-81-8
- Formula:C6H11O9P
- Molecular Weight:258.12
IUPAC Name: (E)-1-(3-methylquinoxalin-2-yl)-3-phenylprop-2-en-1-one
InChIKey: IJOJIVNDFQSGAB-SQOUGZDYSA-N
SMILES: O=P(O)(O)OC[C@@H]1[C@H]([C@@H]([C@H](C(O1)=O)O)O)O
Biological Activity: 6-Phosphoglucono-δ-lactone (6-PGδL), a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD), is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP). 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research[1][2][3].
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6-Phosphoglucono-δ-lactone | 6-Phosphoglucono-δ-lactone (6-PGδL), a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD), is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP). 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research. | |||||||||||||||||||||
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6-Phosphoglucono-d-lactone-13C6 | 6-Phosphoglucono-d-lactone-13C6 (6-PGδL-13C6) is the 13C-labeled 6-Phosphoglucono-d-lactone. | |||||||||||||||||||||
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- [1]. Tyson RL, et al. 6-Aminonicotinamide inhibition of the pentose phosphate pathway in rat neocortex. Neuroreport. 2000;11(9):1845-1848. [Content Brief]
- [2]. Preuss J, et al. Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. J Biomol Screen. 2013;18(3):286-297. [Content Brief]
- [3]. Morales-Luna L, et al. Glucose-6-Phosphate Dehydrogenase::6-Phosphogluconolactonase from the Parasite Giardia lamblia. A Molecular and Biochemical Perspective of a Fused Enzyme. Microorganisms. 2021 Aug 7;9(8):1678. [Content Brief]
