7,8-Dihydroxyflavone

Name: 7,8-Dihydroxyflavone
Brand: MedChemExpress
SKU: HY-W013372
Rating: 5.0 (20 reviews)

製品番号: HY-W013372 純度: 99.58%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 38183-03-8

容量	価格（税別）	在庫状況	数量
25 mg	$60	在庫あり	Estimated Time of Arrival: December 31
50 mg	$88	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 20 publication(s) in Google Scholar

Other Forms of 7,8-Dihydroxyflavone:

7,8-Dihydroxyflavone (Standard) お問い合わせ

顧客検証

Cell Imaging/Staining

: 7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jun 8:132:155803. [Abstract]; 7,8-Dihydroxyflavone (7,8-DHF; 500 nM; 24 h) showed protective effect in PC12 cells. Immunofluorescence staining of MAP-2 expression in PC12 cells.

: 7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jun 8:132:155803. [Abstract]; 7,8-Dihydroxyflavone (7,8-DHF; 500 nM; 24 h) decreased the expression of PSD-95 and F-actin in PC12 cells.

: 7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jun 8:132:155803. [Abstract]; The expression levels of related proteins of BDNF-TrkB signaling pathway by western blot 7,8-Dihydroxyflavone (7,8-DHF; 500 nM).

: 7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jun 8:132:155803. [Abstract]; The expression levels of related proteins of BDNF-TrkB signaling pathway by western blot 7,8-Dihydroxyflavone (7,8-DHF; 500 nM).

: 7,8-Dihydroxyflavone purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jun 8:132:155803. [Abstract]; Immunofluorescence staining of MAP-2 expression primary cortical neurons treated with 7,8-Dihydroxyflavone (7,8-DHF; 500 nM; 24 h).

Trk Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

TrkA TrkB TrkC Trk

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

TrkB

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	37.25 3 Compound: 11a	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 22472167]
A549	IC₅₀	37.25 3 Compound: 11a	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 22472167]
A549	IC₅₀	37.25 3 Compound: 11a	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 22472167]
H9	EC₅₀	10 3 Compound: 10	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay	[PMID: 8158164]
H9	EC₅₀	10 3 Compound: 10	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay	[PMID: 8158164]
H9	IC₅₀	14 3 Compound: 10	Cytotoxicity against human H9 cells after 3 days Cytotoxicity against human H9 cells after 3 days	[PMID: 8158164]
H9	IC₅₀	14 3 Compound: 10	Cytotoxicity against human H9 cells after 3 days Cytotoxicity against human H9 cells after 3 days	[PMID: 8158164]
HEK293	IC₅₀	36 3 Compound: 1b	Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay	[PMID: 15588081]
H9	EC₅₀	10 3 Compound: 10	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay	[PMID: 8158164]
HEK293	IC₅₀	36 3 Compound: Fig 20, R1C3	Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay	10.1039/C0MD00241K
HEK293	IC₅₀	36 3 Compound: 1b	Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay	[PMID: 15588081]
HEK293	IC₅₀	36 3 Compound: Fig 20, R1C3	Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay	10.1039/C0MD00241K
H9	IC₅₀	14 3 Compound: 10	Cytotoxicity against human H9 cells after 3 days Cytotoxicity against human H9 cells after 3 days	[PMID: 8158164]
U-251	IC₅₀	50.11 3 Compound: 11a	Antiproliferative activity against human U251 cells after 24 hrs by MTT assay Antiproliferative activity against human U251 cells after 24 hrs by MTT assay	[PMID: 22472167]
HEK293	IC₅₀	36 3 Compound: 1b	Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay	[PMID: 15588081]
MCF7	IC₅₀	27.5 3 Compound: 3c	The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells	[PMID: 11720850]
U-251	IC₅₀	50.11 3 Compound: 11a	Antiproliferative activity against human U251 cells after 24 hrs by MTT assay Antiproliferative activity against human U251 cells after 24 hrs by MTT assay	[PMID: 22472167]
HEK293	IC₅₀	36 3 Compound: Fig 20, R1C3	Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay	10.1039/C0MD00241K
MCF7	IC₅₀	27.5 3 Compound: 3c	The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells	[PMID: 11720850]
U-251	IC₅₀	50.11 3 Compound: 11a	Antiproliferative activity against human U251 cells after 24 hrs by MTT assay Antiproliferative activity against human U251 cells after 24 hrs by MTT assay	[PMID: 22472167]

体外実験

7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease^[1].

Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

254.24

分子式

C₁₅H₁₀O₄

CAS 番号

38183-03-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (393.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9333 mL	19.6665 mL	39.3329 mL
5 mM	0.7867 mL	3.9333 mL	7.8666 mL
10 mM	0.3933 mL	1.9666 mL	3.9333 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (stored under nitrogen). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.74%

Select Batch:

データシート (275 KB) SDS (393 KB)

COA (249 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9333 mL	19.6665 mL	39.3329 mL	98.3323 mL
	5 mM	0.7867 mL	3.9333 mL	7.8666 mL	19.6665 mL
	10 mM	0.3933 mL	1.9666 mL	3.9333 mL	9.8332 mL
	15 mM	0.2622 mL	1.3111 mL	2.6222 mL	6.5555 mL
	20 mM	0.1967 mL	0.9833 mL	1.9666 mL	4.9166 mL
	25 mM	0.1573 mL	0.7867 mL	1.5733 mL	3.9333 mL
	30 mM	0.1311 mL	0.6555 mL	1.3111 mL	3.2777 mL
	40 mM	0.0983 mL	0.4917 mL	0.9833 mL	2.4583 mL
	50 mM	0.0787 mL	0.3933 mL	0.7867 mL	1.9666 mL
	60 mM	0.0656 mL	0.3278 mL	0.6555 mL	1.6389 mL
	80 mM	0.0492 mL	0.2458 mL	0.4917 mL	1.2292 mL
	100 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.9833 mL