8-Bromo-cAMP (Synonyms: 8-Br-Camp)

Name: 8-Bromo-cAMP
Brand: MedChemExpress
SKU: HY-12306A
Rating: 5.0 (36 reviews)

Cat. No.: HY-12306A Purity: 99.48%: Data Sheet
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8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells.

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CAS No. : 23583-48-4

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

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고객리뷰

Based on 36 publication(s) in Google Scholar

Other Forms of 8-Bromo-cAMP:

8-Bromo-cAMP sodium salt In-stock

36 Publications Citing Use of MCE 8-Bromo-cAMP

Histological Imaging/Staining

Flow Cytometry

: 8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: EMBO J. 2024 Nov;43(21):5018-5036. [Abstract]; Human ESC cell line (hESCs) was treated with 8-Bromo-cAMP sodium salt (0.5 mM; 1-8 days) plus MPA (1 μM) for different times, and western blotting assay was used to detect the expression of CDKN2A, CDKN1A, TP53 (indicator of cell senescence) and PRL.

: 8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: Part Fibre Toxicol. 2022 Feb 17;19(1):13. [Abstract]; Leydig cells were incubated with 0.2 mg/mL PS-MPs for 1 h and then cultured in serum-free medium in the presence of 0.1 mM 8-Bromo-cAMP sodium salt (0.1 mM) for another 24 h. The expression of StAR in cells was analyzed by western blotting.

: 8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: Sci Total Environ. 2022 Oct 10:842:156854. [Abstract]; 8-Bromo-cAMP sodium salt (8-Br-cAMP, 100 μM; 2 h) pretreatment significantly elevated both PKA and p-PKA levels in SiNPs-treated AC16 cells.

: 8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: Sci Total Environ. 2022 Oct 10:842:156854. [Abstract]; 8-Bromo-cAMP sodium salt (8-Br-cAMP, 100 μM; 2 h) pretreatment significantly reduced apoptosis of AC16 cells induced by SiNPs.

: 8-Bromo-cAMP purchased from MedChemExpress. Usage Cited in: Inflammation. 2022 Dec;45(6):2419-2432. [Abstract]; Histopathological changes in the colon tissue sections from from Npr1^−/− mice treated with 8-Bromo-cAMP sodium salt (8-Br-cGMP, 0.1 mM; i.v.; Once daily for 4 weeks) or saline (n = 4).

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PKA PKAR PKACα

Biological Activity
순도&문서
References
고객리뷰

제품 설명

8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells^[1]^[2].

IC₅₀ & Target

PKA^[1]

In Vitro

8-Bromo-cAMP (0.1/0.5 mM) enhances the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells, and 0.1 mM of 8-Bromo-cAMP shows a synergistic effect with Valproic acid (HY-10585) (0.5 mM)^[1].
8-Bromo-cAMP (20 μM, 24 and 48 h) induces apoptosis in esophageal cancer cell line (Eca-109)^[2].
8-Bromo-cAMP (0.5 mM, 2 days) induces decidualization of human endometrial stromal cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

8-Bromo-cAMP (60 mg/kg/day, i.p., 7 days) reduces tumor in CT26 tumor mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CT26 tumor mice^[4]
Dosage:	60 mg/kg/day
Administration:	i.p., 7 days
Result:	Decreases amounts of primary CRC tumor nodules and liver metastases. Reduces vasculogenic mimicry (PAS–CD31 staining of colorectal and intestinal tumors). Inhibits cAMP and VEGF expression, increases expression of PKA in tumor tissues.

분자량

408.10

화학식

C₁₀H₁₁BrN₅O₆P

CAS No.

23583-48-4

Appearance

Solid

Color

White to light yellow

SMILES

OP1(O[C@@]2([H])[C@@H](O)[C@@H](O[C@]2([H])CO1)N3C(Br)=NC4=C3N=CN=C4N)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

1 M NaOH : 100 mg/mL (245.04 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4504 mL	12.2519 mL	24.5038 mL
5 mM	0.4901 mL	2.4504 mL	4.9008 mL
10 mM	0.2450 mL	1.2252 mL	2.4504 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.48%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (250 KB) HNMR (272 KB) RP-HPLC (257 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41. [Content Brief]

[2]. Wang HM, et al. Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol. 2005 Nov 7;11(41):6538-42. [Content Brief]

[3]. Baek MO, et al. Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization. Exp Mol Med. 2018 Oct 30;50(10):1-11. [Content Brief]

[4]. Wang S, et al. Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer. Onco Targets Ther. 2018 Jul 2;11:3765-3774 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

1 M NaOH	1 mM	2.4504 mL	12.2519 mL	24.5038 mL	61.2595 mL
	5 mM	0.4901 mL	2.4504 mL	4.9008 mL	12.2519 mL
	10 mM	0.2450 mL	1.2252 mL	2.4504 mL	6.1259 mL
	15 mM	0.1634 mL	0.8168 mL	1.6336 mL	4.0840 mL
	20 mM	0.1225 mL	0.6126 mL	1.2252 mL	3.0630 mL
	25 mM	0.0980 mL	0.4901 mL	0.9802 mL	2.4504 mL
	30 mM	0.0817 mL	0.4084 mL	0.8168 mL	2.0420 mL
	40 mM	0.0613 mL	0.3063 mL	0.6126 mL	1.5315 mL
	50 mM	0.0490 mL	0.2450 mL	0.4901 mL	1.2252 mL
	60 mM	0.0408 mL	0.2042 mL	0.4084 mL	1.0210 mL
	80 mM	0.0306 mL	0.1531 mL	0.3063 mL	0.7657 mL
	100 mM	0.0245 mL	0.1225 mL	0.2450 mL	0.6126 mL

8-Bromo-cAMP Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Bromo-cAMP23583-48-48-Br-CampPKAApoptosisProtein kinase AHFF1Eca-109endometrial stromal cellInhibitorinhibitorinhibit

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8-Bromo-cAMP (Synonyms: 8-Br-Camp)

고객리뷰

Other Forms of 8-Bromo-cAMP:

8-Bromo-cAMP Related Antibodies

36 Publications Citing Use of MCE 8-Bromo-cAMP

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PKA Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

8-Bromo-cAMP Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

8-Bromo-cAMP Related Classifications

Keywords:

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고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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