2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin

9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin 

Cat. No.: HY-W334680 Purity: 99.45%
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2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin

9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin Chemical Structure

CAS No. : 103884-98-6

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9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin Related Antibodies

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Description

2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Cellular Effect
Cell Line Type Value Description References
B-cell IC50
~ 0.75 μM
Compound: 1(b)
Compound was tested for its cytotoxicity against B- cell line (Wi-L2 B -lymphoblasts)
Compound was tested for its cytotoxicity against B- cell line (Wi-L2 B -lymphoblasts)
[PMID: 3783596]
CCRF-CEM IC50
> 100 μM
Compound: 23
The cytotoxicity against CEM cells
The cytotoxicity against CEM cells
[PMID: 9276020]
HepG2 EC50
> 10 μM
Compound: 23
compound was tested in vitro for anti HBV activity in HepG2 2.2.15 cells
compound was tested in vitro for anti HBV activity in HepG2 2.2.15 cells
[PMID: 9276020]
HepG2 IC50
> 200 μM
Compound: 23
The cytotoxicity against 2.2.15 cells expressed as IC50
The cytotoxicity against 2.2.15 cells expressed as IC50
[PMID: 9276020]
L1210 IC50
8.5 μM
Compound: 1(b)
Effect of compound on macromolecular synthesis in L1210 cells in culture; 8.5-17uM
Effect of compound on macromolecular synthesis in L1210 cells in culture; 8.5-17uM
[PMID: 3783596]
T cell line IC50
~ 0.2 μM
Compound: 1(b)
Compound was tested for its cytotoxicity against wild type T- cell line
Compound was tested for its cytotoxicity against wild type T- cell line
[PMID: 3783596]
Molecular Weight

285.23

Formula

C10H12FN5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](F)[C@H](N2C=NC3=C2NC(N)=NC3=O)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (14.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5059 mL 17.5297 mL 35.0594 mL
5 mM 0.7012 mL 3.5059 mL 7.0119 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5059 mL 17.5297 mL 35.0594 mL 87.6486 mL
5 mM 0.7012 mL 3.5059 mL 7.0119 mL 17.5297 mL
10 mM 0.3506 mL 1.7530 mL 3.5059 mL 8.7649 mL
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9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin103884-98-6Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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