2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. Adrenomedullin (AM) (22-52), human

Adrenomedullin (AM) (22-52), human  (Synonyms: 22-52-Adrenomedullin (human); アドレノメズリン (22-52) (ヒト))

製品番号: HY-P1471 純度: 99.61%
COA 取扱説明書 Technical Support

Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

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Adrenomedullin (AM) (22-52), human

Adrenomedullin (AM) (22-52), human 構造式

CAS 番号 : 159899-65-7

容量 価格（税別） 在庫状況 数量
500 μg $140 在庫あり
1 mg $240 在庫あり
5 mg $520 在庫あり
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* アイテムを追加する前、数量をご選択ください

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Based on 4 publication(s) in Google Scholar

Other Forms of Adrenomedullin (AM) (22-52), human:

Adrenomedullin (AM) (22-52), human 関連抗体

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製品説明

Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat[1][2].

IC50 & Target

Adrenomedullin receptor, CGRP receptor[1]
体外実験

Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist[1].
Adrenomedullin (AM) (22-52), human competitively inhibits the binding of the Adrenomedullin in a dose-dependent manner, inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adrenomedullin (AM) (22-52), human 関連抗体
分子量

3575.98

分子式

C159H252N46O48
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2
Sequence Shortening

TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (27.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (13.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2796 mL 1.3982 mL 2.7964 mL
5 mM 0.0559 mL 0.2796 mL 0.5593 mL
10 mM 0.0280 mL 0.1398 mL 0.2796 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.61%

COA (258 KB) LCMS (94 KB) Elemental Analysis Report (116 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.2796 mL 1.3982 mL 2.7964 mL 6.9911 mL
5 mM 0.0559 mL 0.2796 mL 0.5593 mL 1.3982 mL
10 mM 0.0280 mL 0.1398 mL 0.2796 mL 0.6991 mL
DMSO 15 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.4661 mL
20 mM 0.0140 mL 0.0699 mL 0.1398 mL 0.3496 mL
25 mM 0.0112 mL 0.0559 mL 0.1119 mL 0.2796 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Adrenomedullin (AM) (22-52), human Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adrenomedullin (AM) (22-52), human159899-65-722-52-Adrenomedullin (human)CGRP ReceptorCalcitonin gene-related peptide receptoradrenomedullinreceptorcalcitoninpeptideCGRPhindlimbvascularbedcAMPaccumulationsmoothmuscleInhibitorinhibitorinhibit

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製品名:
Adrenomedullin (AM) (22-52), human
製品番号:
HY-P1471
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