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  2. TokeOni

TokeOni (Synonyms: AkaLumine hydrochloride)

Cat. No.: HY-112641A
Handling Instructions

TokeOni (AkaLumine hydrochloride) is a luciferin analogue, with a Km of 2.06 μM for recombinant Fluc protein.

For research use only. We do not sell to patients.

TokeOni Chemical Structure

TokeOni Chemical Structure

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Customer Review

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TokeOni (AkaLumine hydrochloride) is a luciferin analogue, with a Km of 2.06 μM for recombinant Fluc protein.

IC50 & Target

Km: 2.06 μM (recombinant Fluc protein)[1].

In Vitro

Interestingly, in both LLC/luc and MDA-MB-231/luc cells treated with TokeOni (AkaLumine hydrochloride), the signal is maximal at lower concentrations (by 2.5 μM), whereas the bioluminescence generated by D-luciferin and CycLuc1 increase as concentrations increase further, not appearing to reach a maximal signal even at 250 μM[1].

In Vivo

TokeOni (AkaLumine hydrochloride) displays greatly enhanced signals emanating from metastasis in the lung, as demonstrated by 8.1-fold higher with TokeOni as compared with D-luciferin administration. To evaluate the advantage of TokeOni (AkaLumine hydrochloride) over CycLuc1 in detecting targets in deep tissue, bioluminescence images are compared between TokeOni- and CycLuc1-treated mice 15 min after intravenous injection of LLC/luc cells at the dose of 5 mM, which is the maximum concentration of CycLuc1 due to its low water solubility. TokeOni exhibits 3.3-fold increase in detection sensitivity of disseminated cancer cells in the lung compared with CycLuc1. The advantage of TokeOni is further confirmed by imaging the same mice bearing lung metastasis after intraperitoneal injection of 5 mM substrates in order of CycLuc1 and AkaLumine hydrochloride, and in the inverse order at an 8-h interval. TokeOni displays about fourfold increase in signals from lung metastasis compared with CycLuc1[1].


Please store the product under the recommended conditions in the Certificate of Analysis.

Molecular Weight





O=C([[email protected]@H]1N=C(/C=C/C=C/C2=CC=C(N(C)C)C=C2)SC1)O.Cl


Room temperature in continental US; may vary elsewhere

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Cat. No.: HY-112641A