2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Argireline

Argireline  (Synonyms: Acetyl hexapeptide-3)

製品番号: HY-P0033 純度: 99.86%
COA 取扱説明書 Technical Support

Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity.

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カスタムペプチド

Argireline

Argireline 構造式

CAS 番号 : 616204-22-9

容量 価格（税別） 在庫状況 数量
5 mg $40 在庫あり
10 mg $50 在庫あり
50 mg $69 在庫あり
100 mg $86 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

Other Forms of Argireline:

Argireline 関連抗体

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Calcium Channel アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity[1][2][3].

体外実験

The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Argireline 関連抗体
体内実験

Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

888.99

分子式

C34H60N14O12S
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Sequence Shortening

Ac-EEMQRR-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (112.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1249 mL 5.6244 mL 11.2487 mL
5 mM 0.2250 mL 1.1249 mL 2.2497 mL
10 mM 0.1125 mL 0.5624 mL 1.1249 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (56.24 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.86%

COA (251 KB) RP-HPLC (263 KB) MS (68 KB) Elemental Analysis Report (111 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1249 mL 5.6244 mL 11.2487 mL 28.1218 mL
5 mM 0.2250 mL 1.1249 mL 2.2497 mL 5.6244 mL
10 mM 0.1125 mL 0.5624 mL 1.1249 mL 2.8122 mL
15 mM 0.0750 mL 0.3750 mL 0.7499 mL 1.8748 mL
20 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4061 mL
25 mM 0.0450 mL 0.2250 mL 0.4499 mL 1.1249 mL
30 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9374 mL
40 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.7030 mL
50 mM 0.0225 mL 0.1125 mL 0.2250 mL 0.5624 mL
60 mM 0.0187 mL 0.0937 mL 0.1875 mL 0.4687 mL
80 mM 0.0141 mL 0.0703 mL 0.1406 mL 0.3515 mL
100 mM 0.0112 mL 0.0562 mL 0.1125 mL 0.2812 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Argireline Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Argireline616204-22-9Acetyl hexapeptide-3 Acetyl hexapeptide-8Acetyl hexapeptide3Acetyl hexapeptide 3Acetyl hexapeptide8Acetyl hexapeptide 8Acetyl hexapeptide-8Calcium ChannelCa2+ channelsCa channelsAntiwrinkleanti-agingnon-toxicskin-permeableneurotransmitterBoNTsshort-chainpeptideInhibitorinhibitorinhibit

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