1. Cytoskeleton
  2. Arp2/3 Complex
  3. CK-636

CK-636 (Synonyms: CK-0944636)

Cat. No.: HY-15892 Purity: 98.10%
Handling Instructions

CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC50 values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively.

For research use only. We do not sell to patients.

CK-636 Chemical Structure

CK-636 Chemical Structure

CAS No. : 442632-72-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC50 values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively.

IC50 & Target

IC50: 4/24/32 µM (Human/fission yeast/bovine Arp2/3)[1].

In Vitro

CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. CK-636 prevents actin polymerization and the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50=22 µM)[1]. Additionally, CK-636-treated T cells exhibits elongated morphology with sharp pseudopodia at the leading edges, while the breadth of the CK-636-treated T cells is about 30% less than that of DMSO-treated T cells[2].

Molecular Weight

284.38

Formula

C₁₆H₁₆N₂OS

CAS No.

442632-72-6

SMILES

O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 49 mg/mL (172.30 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5164 mL 17.5821 mL 35.1642 mL
5 mM 0.7033 mL 3.5164 mL 7.0328 mL
10 mM 0.3516 mL 1.7582 mL 3.5164 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (8.79 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CK-636CK-0944636CK636CK 636CK0944636CK 0944636Arp2/3 ComplexActin-related protein 2/3 complexInhibitorinhibitorinhibit

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Product name:
CK-636
Cat. No.:
HY-15892
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