Ceanothic acid (Synonyms: Emmolic acid)

Name: Ceanothic acid
Brand: MedChemExpress
SKU: HY-N3558
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製品番号: HY-N3558 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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Ceanothic acid (Emmolic acid) is an orally active pentacyclic triterpenoid. Ceanothic acid inhibits the growth of various oral bacteria, including Streptococcus mutans, Actinomyces viscosus, Porphyromonas gingivalis, and Prevotella intermedia. Ceanothic acid scavenges DPPH and H₂O₂ free radicals. Ceanothic acid inhibits acetic acid (HY-Y0319)-induced writhing response, xylene-induced ear swelling, and carrageenan-induced paw swelling in mice. Ceanothic acid can be used in research related to oral bacterial infections, ovarian cancer, liver cancer, and liver injury.

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Ceanothic acid 構造式

CAS 番号 : 21302-79-4

容量	価格（税別）	在庫状況	数量
1 mg	$340	在庫あり	Estimated Time of Arrival: December 31
5 mg		お問い合わせ
10 mg		お問い合わせ

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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
C3H 10T1/2	IC₅₀	> 200 μM Compound: 5	Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against mouse C3H10T1/2 cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 18842418]
DU-145	IC₅₀	> 200 μM Compound: 5	Cytotoxicity against human DU145 cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human DU145 cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 18842418]
HaCaT	IC₅₀	> 200 μM Compound: 5	Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells by luciferase based reporter gene assay Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells by luciferase based reporter gene assay	[PMID: 18842418]
HepG2	IC₅₀	> 10 μM Compound: 19	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 27617953]
PANC-1	IC₅₀	195 μM Compound: 5	Cytotoxicity against human PANC1 after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human PANC1 after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 18842418]
Raji	IC₅₀	400 molar ratio Compound: 2, CA	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA induction after 48 hrs relative to TPA Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA induction after 48 hrs relative to TPA	[PMID: 19481937]

体外実験

Ceanothic acid (42-250 μg/mL; 48 hours) inhibits the growth of Actinomyces viscosus, Porphyromonas gingivalis, Prevotella intermedia, and Streptococcus mutans with MIC values of 42 μg/mL, 62 μg/mL, 62 μg/mL, and 250 μg/mL, respectively^[1].
Ceanothic acid (20-100 μg/mL; 30 min) exhibits dose-dependent DPPH free radical scavenging activity, with 14.1% activity at 20 μg/mL and 52.8% activity at 100 μg/mL in a cell-free assay^[2].
Ceanothic acid (48 h) inhibits OVCAR-3, HeLa, and FS-5 cells with the cell survival of 68%, 65%, and 81%, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Ceanothic acid (25-50 mg/kg; p.o.; single dose) exhibits statistically significant antinociceptive activity, with 64.28% inhibition of Acetic acid (HY-Y0319)-induced writhing at 50 mg/kg (p.o.) in BALB/c mice^[2].
Ceanothic acid (25-50 mg/kg; p.o.; single dose) exhibits statistically significant anti-inflammatory activity against Xylene-induced ear edema, with 51.33% inhibition at 50 mg/kg (p.o.) in BALB/c mice^[2].
Ceanothic acid (25-50 mg/kg; i.p.; single dose) exhibits statistically significant anti-inflammatory activity against carrageenan-induced paw edema, with 33.3% inhibition at 50 mg/kg (i.p.) in BALB/c mice 5 hours post-carrageenan injection^[2].
Ceanothic acid (25-50 mg/kg; p.o.; daily; 7 days) exhibits statistically significant hepatoprotective activity against CCl₄ (HY-Y0298)-induced liver injury in BALB/c mice, with more pronounced effects at 50 mg/kg including partial restoration of serum biomarkers, reduction of lipid peroxidation, and improvement of histopathological liver damage^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c (either sex, 20-30 g)^[2]
Dosage:	25 mg/kg; 50 mg/kg
Administration:	p.o.; single dose
Result:	Inhibited acetic acid-induced writhing by a statistically significant level at 25 mg/kg. Inhibited Acetic acid-induced writhing by 64.28% at 50 mg/kg.

Animal Model:	BALB/c (either sex, 20-30 g)^[2]
Dosage:	25 mg/kg; 50 mg/kg
Administration:	p.o.; single dose
Result:	Exhibited 34% inhibitory activity against xylene-induced ear edema at 25 mg/kg. Exhibited 51.33% inhibitory activity against xylene-induced ear edema at 50 mg/kg.

Animal Model:	BALB/c (20-25 g)^[2]
Dosage:	25 mg/kg; 50 mg/kg
Administration:	i.p.; single dose
Result:	Exhibited 13.7% inhibition of carrageenan-induced paw edema at 25 mg/kg 5 hours post-carrageenan injection. Exhibited 33.3% inhibition of carrageenan-induced paw edema at 50 mg/kg 5 hours post-carrageenan injection.

Animal Model:	BALB/c (either sex, 20-30 g, carbon tetrachloride-induced liver injury)^[2]
Dosage:	25 mg/kg; 50 mg/kg
Administration:	p.o.; daily; 7 days
Result:	Significantly reduced CCl₄-induced elevations in serum alanine transaminase (ALT) and alkaline phosphatase (ALP) levels, partially restored serum total protein (TP) levels, and reduced total bilirubin (TB) levels at 25 mg/kg and 50 mg/kg. Did not significantly improve CCl₄-reduced catalase (CAT) and superoxide dismutase (SOD) activity, but reduced CCl₄-induced elevation of malondialdehyde (MDA) levels at 25 mg/kg and 50 mg/kg. Did not significantly reduce CCl₄-prolonged phenobarbital-induced sleeping time at 25 mg/kg; produced a small, non-significant reduction in sleeping time at 50 mg/kg. Caused a 0.99% loss in body weight at 25 mg/kg, and a 0.65% gain in body weight at 50 mg/kg; reduced hepatic index from 8.8% (CCl₄-only group) to 7.4% at 25 mg/kg and 6.5% at 50 mg/kg. Reduced CCl₄-induced centrilobular necrosis, piecemeal necrosis, and lymphocyte infiltration to mild levels, with mild sinusoidal congestion at 25 mg/kg; eliminated centrilobular and piecemeal necrosis, reduced lymphocyte infiltration to mild levels, and left mild sinusoidal congestion at 50 mg/kg.

分子量

486.68

分子式

C₃₀H₄₆O₅

CAS 番号

21302-79-4

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@]([C@]4([C@]([C@]5([H])[C@](C(O)=O)(CC[C@H]5C(C)=C)CC4)([H])CC3)C)(CC[C@@]1([H])C(C)(C)[C@@H](O)[C@@H]2C(O)=O)C

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

純度: 98.0%

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データシート (286 KB) SDS (252 KB)

COA (263 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Li XC, et al. Antimicrobial compounds from Ceanothus americanus against oral pathogens. Phytochemistry. 1997;46(1):97-102.

[2]. Abdullah, et al. Antioxidant, antinociceptive, anti-inflammatory, and hepatoprotective activities of pentacyclic triterpenes isolated from Ziziphus oxyphylla Edgew. Drug Chem Toxicol. 2022 Jul;45(4):1796-1807.

[3]. Lee SS, et al. Preparation and cytotoxic effect of ceanothic acid derivatives. J Nat Prod. 1998 Nov;61(11):1343-7. [Content Brief]

Ceanothic acid Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceanothic acid21302-79-4Emmolic acidBacterialPrevotella intermediaBALB/c miceZiziphus oxyphylla EdgewCeanothus americanusliver injuryPorphyromonas gingivalisStreptococcus mutansoral bacterial infectionsfree radicalsActinomyces viscosusInhibitorinhibitorinhibit

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Ceanothic acid (Synonyms: Emmolic acid)

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Ceanothic acid 関連抗体

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Ceanothic acid 関連抗体

Ceanothic acid Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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