1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefozopran hydrochloride

Cefozopran hydrochloride (Synonyms: SCE-2787 hydrochloride)

Cat. No.: HY-B0771A Purity: 95.07%
Handling Instructions

Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran hydrochloride, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms.

For research use only. We do not sell to patients.

Cefozopran hydrochloride Chemical Structure

Cefozopran hydrochloride Chemical Structure

CAS No. : 113981-44-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 232 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 232 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 211 In-stock
Estimated Time of Arrival: December 31
100 mg USD 319 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. Cefozopran hydrochloride, an antibiotic, has a broad spectrum of antibacterial activity, inhibiting most of the gram-negative and gram-positive organisms[1][2].

In Vitro

Cefozopran (SCE-2787) is a fourth-generation cephalosporin that has good activity against gram-positive organisms including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci; and against gram-negative organisms including hemophilus influenza. Moreover, cefozopran has comparatively good activity against enterococci and P. aeruginosa, which are refractory to other cephalosporins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cefozopran (SCE-2787) (5-80 mg/kg; s.c.; twice a day for 5 days; four-week-old ICR male mice) is effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, Cefozopran (20-80 mg/kg; s.c.; twice a day for 7 days; five-week-old CBA/J female mice) is as effective as Ceftazidime[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

551.99

Formula

C₁₉H₁₈ClN₉O₅S₂

CAS No.
SMILES

[H]Cl.[O-]C(C(N1[[email protected]@]2([H])[[email protected]](NC(/C(C3=NSC(N)=N3)=N\OC)=O)C1=O)=C(CS2)C[N+]4=C(C=CC=N5)N5C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (181.16 mM; Need ultrasonic)

H2O : ≥ 52 mg/mL (94.20 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8116 mL 9.0581 mL 18.1163 mL
5 mM 0.3623 mL 1.8116 mL 3.6233 mL
10 mM 0.1812 mL 0.9058 mL 1.8116 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CefozopranSCE-2787SCE2787SCE 2787BacterialAntibioticantibacterialfourth-generationgram-negativegram-positiveorganismscephalosporintractrespiratorymiceInhibitorinhibitorinhibit

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Cefozopran hydrochloride
Cat. No.:
HY-B0771A
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