1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Chembridge-5861528

Chembridge-5861528 (Synonyms: TCS 5861528)

Cat. No.: HY-15065 Purity: 99.27%
Handling Instructions

Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).

For research use only. We do not sell to patients.

Chembridge-5861528 Chemical Structure

Chembridge-5861528 Chemical Structure

CAS No. : 332117-28-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 840 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).

Molecular Weight

369.42

Formula

C₁₉H₂₃N₅O₃

CAS No.

332117-28-9

SMILES

O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)CC)C=C3)=O)N(C)C(N1C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (324.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7069 mL 13.5347 mL 27.0695 mL
5 mM 0.5414 mL 2.7069 mL 5.4139 mL
10 mM 0.2707 mL 1.3535 mL 2.7069 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (8.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (8.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Chembridge-5861528TCS 5861528Chembridge5861528Chembridge 5861528TCS5861528TCS-5861528TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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Product Name:
Chembridge-5861528
Cat. No.:
HY-15065
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