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Cremophor EL-40  (Synonyms: Polyoxyethylene(40) Castor Oil; PEG-40 Castor Oil)

Cat. No.: HY-Y1890 Assay: 99.59%
COA
SDS
Instrucciones de manejo Technical Support

Cremophor EL-40, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL-40 is widely employed to improve dissolution and delivery of agents.

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Cremophor EL-40

Cremophor EL-40 Estructura química

No. CAS : 61791-12-6

Tamaño Precio Stock Cantidad
Solvent
100 mL En stock
200 mL   Obtener un presupuesto  
500 mL   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

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Revisión del cliente

Based on 21 publication(s) in Google Scholar

Other Forms of Cremophor EL-40:

Cremophor EL-40 Related Antibodies

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Descripciòn

Cremophor EL-40, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL-40 is widely employed to improve dissolution and delivery of agents[1].

In Vitro

Cremophor EL-40 is a widely used excipient. In the first 10 h, Cremophor EL-40 at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL-40 decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL-40 at 24-h treatment. Cremophor EL-40 also enhances cell detachment[1].
Note:
Due to the nature of the product, it may solidify after being stored at 4°C. It can be heated in a 37°C water bath before use. It can be used normally after it is completely dissolved.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cremophor EL-40 Related Antibodies
No. CAS
Appearance

Liquid (Density: 1.05 g/mL)

Color

Light yellow to brown

SMILES

[Cremophor EL-40]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

H2O : 133.33 mg/mL (Need ultrasonic)

Ethanol : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 99.59%

SDS (394 KB)

COA (240 KB)

Instrucciones de manejo (2659 KB)
Referencias
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Cremophor EL-40 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cremophor EL-4061791-12-6Polyoxyethylene(40) Castor Oil PEG-40 Castor OilCremophor EL40Cremophor EL 40Biochemical Assay ReagentsEnvironmental PollutantsEnvironmental ContaminantsInhibitorinhibitorinhibit

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Nombre del producto:
Cremophor EL-40
Cat. No.:
HY-Y1890
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