1. GPCR/G Protein
  2. Glucagon Receptor
  3. GLP-1(7-36), amide

GLP-1(7-36), amide (Synonyms: Glucagon-like peptide-1 (GLP-1)(7-36), amide; Human GLP-1 (7-36), amide)

Cat. No.: HY-P0054A
Handling Instructions

GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretion.

For research use only. We do not sell to patients.

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GLP-1(7-36), amide Chemical Structure

GLP-1(7-36), amide Chemical Structure

CAS No. : 107444-51-9

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Description

GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretion.

In Vitro

The sequence of Glucagon-Like Peptide after residue 7 shows similarities to glucagon and to other biologically active members of the secretin peptide family, particularly glucose-dependent insulinotropic peptide (GIP). This sequence has been especially well preserved, showing 66% nucleotide homology with GLP-1 in the proglucagon of the very primitive anglerfish. This 7-36 sequence of GLP-1 is a potent insulin-releasing peptide in vitro[1]. Glucagon-Like Peptide (GLP) I (7-36), amide is a product of the tissue-specific post-translational processing of the glucagon precursor. It is released postprandially from intestinal endocrine L cells and stimulates insulin secretion. DPP IV is the main degradation enzyme for GLP-l(7 - 36)amide in human serum. Dipeptidyl-peptidase IV can initiate the metabolism of GIP and GLP-1(7-36)amide in human serum[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Glucagon-Like Peptide (GLP) I (7-36), amide is a physiological incretin hormone that is released after nutrient intake from the lower gut and stimulates insulin secretion at elevated plasma glucose concentrations. Exogenous GLP-1 (7-36 amide) is an effective means of normalizing fasting plasma glucose concentrations in poorly-controlled Type 2 diabetic subjects[3]. Exogenously administered GLP-1-(7–36)amide is extremely labile in vivo, with more than 80% being cleaved into GLP-1-(9–36)amide after sc or iv administration[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3297.68

Formula

C₁₄₉H₂₂₆N₄₀O₄₅

CAS No.

107444-51-9

Sequence

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Sequence Shortening

HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GLP-1(7-36), amideGlucagon-like peptide-1 (GLP-1)(7-36), amide Human GLP-1 (7-36), amideGlucagon ReceptorGCGRInhibitorinhibitorinhibit

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GLP-1(7-36), amide
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