IFN alpha-IFNAR-IN-1

Name: IFN alpha-IFNAR-IN-1
Brand: MedChemExpress
SKU: HY-12836
Rating: 5.0 (25 reviews)

Cat. No.: HY-12836 Purity: 98.43%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC₅₀=2-8 μM).

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CAS No. : 844882-93-5

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 25 publication(s) in Google Scholar

Other Forms of IFN alpha-IFNAR-IN-1:

IFN alpha-IFNAR-IN-1 hydrochloride In-stock

25 Publications Citing Use of MCE IFN alpha-IFNAR-IN-1

: IFN alpha-IFNAR-IN-1 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2016 Jul 14;6:29665. [Abstract]; PAMs are first pretreated with IFN-alpha-IFNAR-IN-1 or mock pretreated with medium containing DMSO for 2 h. The cells are then infected with the HP-PRRSV virus at an MOI of 5 or mock-infected with DMEM for 12 h and 16 h, respectively. The cell lysates are collected and analyzed by western blot. The fold change of SAMHD1 protein is expressed as densitometric units of the band normalized to the β-actin level relative to the uninfected control. The error bar represents standard deviation from three

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) specifically inhibits MVA-induced IFN-a responses by BMpDCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

279.40

화학식

C₁₈H₁₇NS

CAS No.

844882-93-5

Appearance

Solid-Liquid Mixture

Color

Light yellow to yellow

SMILES

CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2

선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 100 mg/mL (357.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5791 mL	17.8955 mL	35.7910 mL
5 mM	0.7158 mL	3.5791 mL	7.1582 mL
10 mM	0.3579 mL	1.7895 mL	3.5791 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.43%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (251 KB) HNMR (403 KB) RP-HPLC (263 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5791 mL	17.8955 mL	35.7910 mL	89.4775 mL
	5 mM	0.7158 mL	3.5791 mL	7.1582 mL	17.8955 mL
	10 mM	0.3579 mL	1.7895 mL	3.5791 mL	8.9477 mL
	15 mM	0.2386 mL	1.1930 mL	2.3861 mL	5.9652 mL
	20 mM	0.1790 mL	0.8948 mL	1.7895 mL	4.4739 mL
	25 mM	0.1432 mL	0.7158 mL	1.4316 mL	3.5791 mL
	30 mM	0.1193 mL	0.5965 mL	1.1930 mL	2.9826 mL
	40 mM	0.0895 mL	0.4474 mL	0.8948 mL	2.2369 mL
	50 mM	0.0716 mL	0.3579 mL	0.7158 mL	1.7895 mL
	60 mM	0.0597 mL	0.2983 mL	0.5965 mL	1.4913 mL
	80 mM	0.0447 mL	0.2237 mL	0.4474 mL	1.1185 mL
	100 mM	0.0358 mL	0.1790 mL	0.3579 mL	0.8948 mL