1. Metabolic Enzyme/Protease
    GPCR/G Protein
  2. FXR
    GPCR19
  3. INT-767

INT-767 

Cat. No.: HY-12434 Purity: >98.0%
Handling Instructions

INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.

For research use only. We do not sell to patients.

INT-767 Chemical Structure

INT-767 Chemical Structure

CAS No. : 1000403-03-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 990 In-stock
Estimated Time of Arrival: December 31
5 mg USD 900 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
50 mg USD 4320 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE INT-767

    INT-767 purchased from MCE. Usage Cited in: J Am Soc Nephrol. 2018 Nov;29(11):2658-2670.

    Western blots show that INT-767, INT-777, and INT747 upregulate AQP2 protein expression.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively[1][2].

    In Vitro

    INT-767 does not show cytotoxic effects in HepG2 cells, does not inhibit cytochrome P450 enzymes, is highly stable to phase I and II enzymatic modifications, and does not inhibit the human ether-a-go-go-related gene potassium channel[2].

    In Vivo

    INT-767 (10-20 mg/kg; i.p.; daily for 2 weeks) decreases plasma total cholesterol and triglyceride levels in db/m and db/db mice [2].

    Animal Model: Male 8-week old C57BKS/J db/db mice, control nondiabetic db/m mice[2]
    Dosage: 10, 20 mg/kg
    Administration: Intraperitoneal injection; daily for 2 weeks
    Result: Decreased plasma total cholesterol and triglyceride levels.
    Molecular Weight

    494.66

    Formula

    C₂₅H₄₃NaO₆S

    CAS No.

    1000403-03-1

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 205.5 mg/mL (415.44 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0216 mL 10.1080 mL 20.2159 mL
    5 mM 0.4043 mL 2.0216 mL 4.0432 mL
    10 mM 0.2022 mL 1.0108 mL 2.0216 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: >98.0%

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    Product Name:
    INT-767
    Cat. No.:
    HY-12434
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