1. Anti-infection
  2. HBV
  3. Inarigivir

Inarigivir (Synonyms: ORI-9020; SB-9000)

Cat. No.: HY-101954
Handling Instructions

Inarigivir (ORI-9020) is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) act as a RIG-I agonist to activate cellular innate immune responses.

For research use only. We do not sell to patients.

Inarigivir Chemical Structure

Inarigivir Chemical Structure

CAS No. : 475650-36-3

Size Price Stock Quantity
5 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Inarigivir:

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  • Biological Activity

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Description

Inarigivir (ORI-9020) is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) act as a RIG-I agonist to activate cellular innate immune responses[1][2].

IC50 & Target

Target: HBV[1]

In Vitro

Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 100 mg/kg.
Administration: IP, daily.
Result: Significantly reduced viral DNA in the liver and shows anti-HBV activity similar ADV positive control.
Clinical Trial
Molecular Weight

587.50

Formula

C20H26N7O10PS

CAS No.
SMILES

NC1=C(N=CN2[[email protected]@H]3O[[email protected]](COP(O[[email protected]]4[[email protected]@H](OC)[[email protected]](N5C=CC(NC5=O)=O)O[[email protected]@H]4CO)(S)=O)[[email protected]@H](O)C3)C2=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (340.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7021 mL 8.5106 mL 17.0213 mL
5 mM 0.3404 mL 1.7021 mL 3.4043 mL
10 mM 0.1702 mL 0.8511 mL 1.7021 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

  • 3.

    Add each solvent one by one:  1% DMSO    99% saline

    Solubility: ≥ 0.25 mg/mL (0.43 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.20%

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Product Name:
Inarigivir
Cat. No.:
HY-101954
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