1. Anti-infection
  2. HBV

Inarigivir (Synonyms: ORI-9020; SB-9000)

Cat. No.: HY-101954
Handling Instructions

Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.

For research use only. We do not sell to patients.

Inarigivir Chemical Structure

Inarigivir Chemical Structure

CAS No. : 475650-36-3

Size Price Stock
5 mg USD 1500 Get quote
10 mg USD 2200 Get quote
50 mg USD 6600 Get quote
100 mg USD 9200 Get quote

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.

IC50 & Target

Target: HBV[1]

In Vivo

I.p. injection of Inarigivir at 100 mg/kg/day significantly reduces viral DNA in the liver and shows anti-HBV activity similar ADV positive control. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7021 mL 8.5106 mL 17.0213 mL
5 mM 0.3404 mL 1.7021 mL 3.4043 mL
10 mM 0.1702 mL 0.8511 mL 1.7021 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[1]

Inarigivir is prepared in sterile saline[1].

Mice[1]

For the first animal experiment, Inarigivir is prepared fresh daily at a dosage of 100 mg/kg of body weight /day, which is equal to 170 mol/kg/day, and is injected intraperitoneally (i.p.) using cremaphor-ethanol-saline (CES) (10:10:80) or physiological saline as vehicles. ADV, the positive control, is prepared using the CES vehicle. A dosage of 10 mg/kg/day (19.9 mol/kg/day) is used. In the second experiment to determine the minimal effective concentration, Inarigivir is prepared in sterile saline in onehalf-log dilutions from 50 to 0.05 mg/kg/day. The drug is delivered i.p. in a volume of 0.1 ml. Liver samples are analyzed for HBV DNA, HBV RNA, and HBcAg, and serum samples are processed for HBV DNA, HBeAg, and HBsAg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

587.5

Formula

C₂₀H₂₆N₇O₁₀PS

CAS No.

475650-36-3

SMILES

NC1=C(N=CN2[[email protected]@H]3O[[email protected]](COP(O[[email protected]]4[[email protected]@H](OC)[[email protected]](N5C=CC(NC5=O)=O)O[[email protected]@H]4CO)(S)=O)[[email protected]@H](O)C3)C2=NC=N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Inarigivir
Cat. No.:
HY-101954
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