1. Anti-infection
  2. HBV
  3. Inarigivir ammonium

Inarigivir ammonium (Synonyms: ORI-9020 ammonium; SB-9000 ammonium)

Cat. No.: HY-101954A
Handling Instructions

Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium act as a RIG-I agonist to activate cellular innate immune responses.

For research use only. We do not sell to patients.

Inarigivir ammonium Chemical Structure

Inarigivir ammonium Chemical Structure

CAS No. : 2172788-92-8

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1 mg USD 490 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2050 In-stock
Estimated Time of Arrival: December 31
50 mg USD 6000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 9000 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Inarigivir ammonium:

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Description

Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium act as a RIG-I agonist to activate cellular innate immune responses[1][2].

IC50 & Target

Target: HBV[1].

In Vitro

Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 100 mg/kg.
Administration: IP, daily.
Result: Significantly reduced viral DNA in the liver and shows anti-HBV activity similar ADV positive control.
Molecular Weight

604.53

Formula

C₂₀H₂₉N₈O₁₀PS

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (165.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6542 mL 8.2709 mL 16.5418 mL
5 mM 0.3308 mL 1.6542 mL 3.3084 mL
10 mM 0.1654 mL 0.8271 mL 1.6542 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Inarigivir ammonium
Cat. No.:
HY-101954A
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