2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. Insulin (human)

Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus.

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No. CAS : 11061-68-0

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Based on 92 publication(s) in Google Scholar

Other Forms of Insulin (human):

Insulin (human) Related Antibodies

Top Publications Citing Use of Products

92 Publications Citing Use of MCE Insulin (human)

IF
Bio/Physico-chemical Assay
WB

    Insulin (human) purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 4;10(1):361.  [Abstract]

    Tissues from GIST patient samples were digested and resuspended in GIST primary cell culture medium, 1% Anti-Anti, 50 ng/mL SCF, 125 ng/mL EGF, 20 ng/mL bFGF (HY-P7004), 25 ng/mL Hydrocortisone (HY-N0583), and 5 µg/mL Insulin. Olverembatinib inhibited lipid droplet accumulation and lipid uptake in SDH-deficient GIST primary cells and downregulated CD36 in primary SDH-deficient GIST cells..

    Insulin (human) purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 4;10(1):361.  [Abstract]

    Tissues from GIST patient samples were digested and resuspended in GIST primary cell culture medium, 1% Anti-Anti, 50 ng/mL SCF, 125 ng/mL EGF, 20 ng/mL bFGF (HY-P7004), 25 ng/mL Hydrocortisone (HY-N0583), and 5 µg/mL Insulin. Olverembatinib inhibited lipid droplet accumulation and lipid uptake in SDH-deficient GIST primary cells and downregulated CD36 in primary SDH-deficient GIST cells.

    Insulin (human) purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Nov 7;12(18):7699-7716.  [Abstract]

    For insulin tolerance tests, mice on HFD for 15 weeks received an intraperitoneal injection of Insulin (1.0 U/kg body weight) after 6 hours of fasting. Glucose level was measured in tail blood at 0, 15, 30, 60, 90, and 120 mins after glucose or insulin injection using a glucometer.

    Insulin (human) purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 Mar 26;10(10):4705-4719.   [Abstract]

    Insulin tolerance tests (ITT) were performed by intraperitoneally injecting Insulin (0.75 unit/kg in 0.9% wt/vol saline) to mice that had been fasted for 6 h. Blood glucose levels were measured at 0, 15, 30, 60, and 120 minutes using an Infinity glucose meter.

    • Actividad biológica

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus[1][2].

    In Vitro

    The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region[1]. Human insulin is commonly used to treat type 2 diabetes[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Insulin (human) Related Antibodies
    In Vivo

    Insulin (human) (0.75 U/kg; ip; once) can significantly reduce blood glucose levels in 15 minutes[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Slc35d3-Flox mice and Slc35d3-wild type mice injected with 100 mg/mLl D-Glucose (HY-B0389)[1]
    Dosage: 0.75 U/kg
    Administration: ip; once
    Result: Significantly lowers blood glucose levels.
    Peso molecular

    5807.57

    Fòrmula

    C257H383N65O77S6
    No. CAS
    Appearance

    Solid

    Color

    White to off-white

    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvente y solubilidad
    In Vitro: 

    H2O : 10 mg/mL (1.72 mM; ultrasonic and adjust pH to 2 with HCl)

    1 M Acetic acid : ≥ 10 mg/mL (1.72 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.1722 mL 0.8609 mL 1.7219 mL
    5 mM --- --- ---
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

    • Protocol 1

      Insulin(human)solution in dilute hydrochloric acid(pH:2~3)is diluted with PBS.(clear)

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureza y Documentación

    Purity: 100.6%%

    SDS (397 KB)

    COA (241 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / 1 M Acetic acid 1 mM 0.1722 mL 0.8609 mL 1.7219 mL 4.3047 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Insulin (human) Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Insulin (human)11061-68-0Insulin ReceptorInhibitorinhibitorinhibit

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    Nombre del producto:
    Insulin (human)
    Cat. No.:
    HY-P0035
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