Kisspeptin-10, human

Name: Kisspeptin-10, human
Brand: MedChemExpress
SKU: HY-P0254
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0254 Purity: 99.86%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.

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Custom Peptide Synthesis

Kisspeptin-10, human 화학구조

CAS No. : 374675-21-5

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

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고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Kisspeptin-10, human:

Kisspeptin-10 (mouse, rat) In-stock
Kisspeptin-10, human TFA In-stock

1 Publications Citing Use of MCE Kisspeptin-10, human

•ACS Pharmacol Transl Sci. 2025 Jun 6;8(7):2048-2060. [Abstract]

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

GPR54^[1]
Angiogenesis^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.07 1 Compound: kisspeptin-10	Displacement of [125I]kisspeptin-15 from human GPR54 expressed in CHO cell membrane Displacement of [125I]kisspeptin-15 from human GPR54 expressed in CHO cell membrane	[PMID: 19007202]
CHO	EC₅₀	0.087 1 Compound: Metastin	Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay	[PMID: 30598349]
CHO	EC₅₀	0.087 1 Compound: Metastin	Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay	[PMID: 30598349]
CHO	EC₅₀	0.24 1 Compound: kisspeptin-10	Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay	[PMID: 19007202]
CHO	EC₅₀	0.24 1 Compound: kisspeptin-10	Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay	[PMID: 19007202]
CHO	EC₅₀	0.087 1 Compound: Metastin	Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay	[PMID: 30598349]
CHO	EC₅₀	0.96 1 Compound: Metastin(45-54)	Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	EC₅₀	0.24 1 Compound: kisspeptin-10	Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay	[PMID: 19007202]
CHO	EC₅₀	0.96 1 Compound: Metastin(45-54)	Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	EC₅₀	4.2 1 Compound: Metastin(45-54)	Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	EC₅₀	0.96 1 Compound: Metastin(45-54)	Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	EC₅₀	4.2 1 Compound: Metastin(45-54)	Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	IC₅₀	8510 1 Compound: Metastin(45-54)	Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay	[PMID: 24047141]
CHO	EC₅₀	4.2 1 Compound: Metastin(45-54)	Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	IC₅₀	0.07 1 Compound: kisspeptin-10	Displacement of [125I]kisspeptin-15 from human GPR54 expressed in CHO cell membrane Displacement of [125I]kisspeptin-15 from human GPR54 expressed in CHO cell membrane	[PMID: 19007202]
HEK293	EC₅₀	17.3 1 Compound: 10-mer, metastin-10	Activity at metastin receptor expressed in HEK293 cells by measuring calcium release Activity at metastin receptor expressed in HEK293 cells by measuring calcium release	[PMID: 17266198]
HEK293	EC₅₀	17.3 1 Compound: 10-mer, metastin-10	Activity at metastin receptor expressed in HEK293 cells by measuring calcium release Activity at metastin receptor expressed in HEK293 cells by measuring calcium release	[PMID: 17266198]
CHO	IC₅₀	8510 1 Compound: Metastin(45-54)	Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay	[PMID: 24047141]
CHO	IC₅₀	8510 1 Compound: Metastin(45-54)	Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay	[PMID: 24047141]
HEK293	EC₅₀	17.3 1 Compound: 10-mer, metastin-10	Activity at metastin receptor expressed in HEK293 cells by measuring calcium release Activity at metastin receptor expressed in HEK293 cells by measuring calcium release	[PMID: 17266198]

In Vitro

Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

1302.44

화학식

C₆₃H₈₃N₁₇O₁₄

CAS No.

374675-21-5

Appearance

Solid

Color

White to off-white

Sequence

Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

Sequence Shortening

YNWNSFGLRF-NH2

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

H₂O : 10 mg/mL (7.68 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7678 mL	3.8389 mL	7.6779 mL
5 mM	0.1536 mL	0.7678 mL	1.5356 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.86%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (109 KB) MS (214 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

References

[1]. Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.7678 mL	3.8389 mL	7.6779 mL	19.1947 mL
H₂O	5 mM	0.1536 mL	0.7678 mL	1.5356 mL	3.8389 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.