Kisspeptin-10, human TFA

Name: Kisspeptin-10, human TFA
Brand: MedChemExpress
SKU: HY-P0254A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P0254A Purity: 95.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Kisspeptin-10, human TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Kisspeptin-10, human TFA Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Kisspeptin-10, human TFA:

Kisspeptin-10, human In-stock

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

GPR54^[1]
Angiogenesis^[1]

In Vitro

Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nM) induces a dose-dependent increase in LH secretion. The stimulatory effect of kisspeptin-10 (100 n nM) on LH secretion is blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes^[4]. Kisspeptin-10 inhibits angiogenesis in vivo. Kp-10 inhibits tumor growth in SCID mice xenografted with human prostate cancer cells (PC-3) through inhibiting tumor angiogenesis^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1416.46

Formula

C₆₃H₈₃N₁₇O₁₄.C₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence Shortening

YNWNSFGLRF-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (70.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 4 mg/mL (2.82 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7060 mL	3.5299 mL	7.0599 mL
5 mM	0.1412 mL	0.7060 mL	1.4120 mL
10 mM	0.0706 mL	0.3530 mL	0.7060 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.89%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (242 KB) LCMS (92 KB) Elemental Analysis Report (101 KB)

Handling Instructions (2659 KB)

References

[1]. Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.7060 mL	3.5299 mL	7.0599 mL	17.6496 mL
DMSO	5 mM	0.1412 mL	0.7060 mL	1.4120 mL	3.5299 mL
	10 mM	0.0706 mL	0.3530 mL	0.7060 mL	1.7650 mL
	15 mM	0.0471 mL	0.2353 mL	0.4707 mL	1.1766 mL
	20 mM	0.0353 mL	0.1765 mL	0.3530 mL	0.8825 mL
	25 mM	0.0282 mL	0.1412 mL	0.2824 mL	0.7060 mL
	30 mM	0.0235 mL	0.1177 mL	0.2353 mL	0.5883 mL
	40 mM	0.0176 mL	0.0882 mL	0.1765 mL	0.4412 mL
	50 mM	0.0141 mL	0.0706 mL	0.1412 mL	0.3530 mL
	60 mM	0.0118 mL	0.0588 mL	0.1177 mL	0.2942 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.