Kisspeptin-10, human

Name: Kisspeptin-10, human
Brand: MedChemExpress
SKU: HY-P0254
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-P0254 Reinheit: 99.86%: Data Sheet
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Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression.

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Kundenspezifische Peptidsynthese

Kisspeptin-10, human Chemische Struktur

CAS. Nr. : 374675-21-5

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Kisspeptin-10, human:

Kisspeptin-10 (mouse, rat) In-stock
Kisspeptin-10, human TFA In-stock

1 Publications Citing Use of MCE Kisspeptin-10, human

•ACS Pharmacol Transl Sci. 2025 Jun 6;8(7):2048-2060. [Abstract]

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

IC₅₀ & Target

GPR54^[1]
Angiogenesis^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.07 1 Compound: kisspeptin-10	Displacement of [125I]kisspeptin-15 from human GPR54 expressed in CHO cell membrane Displacement of [125I]kisspeptin-15 from human GPR54 expressed in CHO cell membrane	[PMID: 19007202]
CHO	EC₅₀	0.087 1 Compound: Metastin	Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay	[PMID: 30598349]
CHO	EC₅₀	0.087 1 Compound: Metastin	Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay	[PMID: 30598349]
CHO	EC₅₀	0.24 1 Compound: kisspeptin-10	Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay	[PMID: 19007202]
CHO	EC₅₀	0.24 1 Compound: kisspeptin-10	Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay	[PMID: 19007202]
CHO	EC₅₀	0.087 1 Compound: Metastin	Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay Agonist activity at human KISS1R expressed in CHO cells assessed as increase in calcium mobilization measured at 2 secs interval for 2 mins by fluo-4 NW dye based FLIPR assay	[PMID: 30598349]
CHO	EC₅₀	0.96 1 Compound: Metastin(45-54)	Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	EC₅₀	0.24 1 Compound: kisspeptin-10	Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay Agonist activity at human GPR54 expressed in CHO cells assessed as effect on kisspeptin-10-induced response by FLIPR assay	[PMID: 19007202]
CHO	EC₅₀	0.96 1 Compound: Metastin(45-54)	Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	EC₅₀	4.2 1 Compound: Metastin(45-54)	Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	EC₅₀	0.96 1 Compound: Metastin(45-54)	Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at human KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	EC₅₀	4.2 1 Compound: Metastin(45-54)	Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	IC₅₀	8510 1 Compound: Metastin(45-54)	Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay	[PMID: 24047141]
CHO	EC₅₀	4.2 1 Compound: Metastin(45-54)	Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay Agonist activity at rat KISS1R transfected in CHO cells assessed as intracellular calcium flux after 24 hrs by functional FLIPR assay	[PMID: 24918545]
CHO	IC₅₀	0.07 1 Compound: kisspeptin-10	Displacement of [125I]kisspeptin-15 from human GPR54 expressed in CHO cell membrane Displacement of [125I]kisspeptin-15 from human GPR54 expressed in CHO cell membrane	[PMID: 19007202]
HEK293	EC₅₀	17.3 1 Compound: 10-mer, metastin-10	Activity at metastin receptor expressed in HEK293 cells by measuring calcium release Activity at metastin receptor expressed in HEK293 cells by measuring calcium release	[PMID: 17266198]
HEK293	EC₅₀	17.3 1 Compound: 10-mer, metastin-10	Activity at metastin receptor expressed in HEK293 cells by measuring calcium release Activity at metastin receptor expressed in HEK293 cells by measuring calcium release	[PMID: 17266198]
CHO	IC₅₀	8510 1 Compound: Metastin(45-54)	Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay	[PMID: 24047141]
CHO	IC₅₀	8510 1 Compound: Metastin(45-54)	Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay Inhibition of human KISS1R expressed in CHO cells assessed as inhibition of KISS1R-mediated cell growth after 4 days by cell counting kit-8 assay	[PMID: 24047141]
HEK293	EC₅₀	17.3 1 Compound: 10-mer, metastin-10	Activity at metastin receptor expressed in HEK293 cells by measuring calcium release Activity at metastin receptor expressed in HEK293 cells by measuring calcium release	[PMID: 17266198]

In Vitro

Kisspeptin-10 (KP-10) and its receptor GPR54 are key components in the regulation of GnRH secretion in humans and other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma and Kisspeptin-10 is a metastasis suppressor in breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

1302.44

Formel

C₆₃H₈₃N₁₇O₁₄

CAS. Nr.

374675-21-5

Appearance

Solid

Color

White to off-white

Sequence

Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

Sequence Shortening

YNWNSFGLRF-NH2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 10 mg/mL (7.68 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7678 mL	3.8389 mL	7.6779 mL
5 mM	0.1536 mL	0.7678 mL	1.5356 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.86%

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Data Sheet (270 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (109 KB) MS (214 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Son HE, et al. Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep. 2018 Feb 1;8(1):2134. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.7678 mL	3.8389 mL	7.6779 mL	19.1947 mL
H₂O	5 mM	0.1536 mL	0.7678 mL	1.5356 mL	3.8389 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.