1. MAPK/ERK Pathway
  2. JNK
  3. L-JNKI-1


Cat. No.: HY-P0069A Purity: 95.50%
Handling Instructions

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

L-JNKI-1 Chemical Structure

L-JNKI-1 Chemical Structure

Size Price Stock Quantity
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 360 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1380 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.

IC50 & Target



In Vivo

L-JNKI-1 has been shown to effectively inhibit JNK activity in in vivo studies. It is shown that Ang II induces a dose-dependent pressor response, which was significantly attenuated by JNK inhibition[1]. It is also found that 10 μM L-JNKI-1 decreases phosphorylated c-Jun by 98% and phosphorylated Elk-1 by 100%. L-JNKI-1 is able to across the blood-brain barrier and penetrate neurons of adult mice and P5 rats within 1 h after an intraperitoneal injection[2].

Molecular Weight






Sequence Shortening



Room temperature in continental US; may vary elsewhere.

Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (26.16 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2616 mL 1.3081 mL 2.6161 mL
5 mM 0.0523 mL 0.2616 mL 0.5232 mL
10 mM 0.0262 mL 0.1308 mL 0.2616 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Six-week-old male SD rats are used. The rats are injected with a bolus of JNK peptide inhibitor L-JNKI-1 (5 mg/kg) followed by infusion of JNKI 1 (5 mg/kg per hour) until the completion of the experiment. After a 30-minute infusion of JNK inhibitor, the pressor response to Ang II at the 3 doses described above is determined at 30-minute intervals[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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L-JNKI-1JNKc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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