1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Sotagliflozin

Sotagliflozin (Synonyms: LX-4211; LP-802034)

Cat. No.: HY-15516 Purity: 99.99%
Handling Instructions

Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.

For research use only. We do not sell to patients.

Sotagliflozin Chemical Structure

Sotagliflozin Chemical Structure

CAS No. : 1018899-04-1

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10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
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10 mg USD 150 In-stock
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25 mg USD 290 In-stock
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50 mg USD 450 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Sotagliflozin purchased from MCE. Usage Cited in: J Nutr. 2020 May 29;nxaa125.

    Effects of LX-4211 pretreatment on glucose-induced changes in protein expression in IECs of yellow catfish. Primary IECs are incubated in control or glucose (15 mM glucose) for 24 h with or without 2-h pretreatment with an SGLT1/2 dual inhibitor LX-4211 (20 μM).
    • Biological Activity

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    Description

    Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.

    IC50 & Target

    SGLT1/2

    In Vitro

    LX4211 enhanced urinary glucose excretion by inhibiting SGLT2-mediated renal glucose reabsorption; markedly and significantly improved multiple measures of glycemic control, including fasting plasma glucose, oral glucose tolerance, and HbA(1c); and significantly lowered serum triglycerides. LX4211 also mediated trends for lower weight, lower blood pressure, and higher glucagon-like peptide-1 levels. In a follow-up single-dose study in 12 patients with T2DM, LX4211 (300 mg) significantly increased glucagon-like peptide-1 and peptide YY levels relative to pretreatment values, probably by delaying SGLT1-mediated intestinal glucose absorption [1]. LX4211-treated mice and SGLT1-/- mice also had increased GLP-1 AUC values, decreased glucose-dependent insulinotropic polypeptide (GIP) AUC values, and decreased blood glucose excursions during the 6 hours after a challenge with oral glucose alone [2].

    Clinical Trial
    Molecular Weight

    424.94

    Formula

    C₂₁H₂₅ClO₅S

    CAS No.

    1018899-04-1

    SMILES

    ClC(C=CC([[email protected]@H]1O[[email protected]](SC)[[email protected]@H](O)[[email protected]](O)[[email protected]]1O)=C2)=C2CC3=CC=C(OCC)C=C3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (235.33 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3533 mL 11.7664 mL 23.5327 mL
    5 mM 0.4707 mL 2.3533 mL 4.7065 mL
    10 mM 0.2353 mL 1.1766 mL 2.3533 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.99%

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    Keywords:

    SotagliflozinLX-4211LP-802034LX4211LX 4211LP802034LP 802034SGLTSodium-dependent glucose cotransportersInhibitorinhibitorinhibit

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