1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Sotagliflozin

Sotagliflozin (Synonyms: LX-4211; LP-802034)

Cat. No.: HY-15516 Purity: 99.99%
Handling Instructions

Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.

For research use only. We do not sell to patients.

Sotagliflozin Chemical Structure

Sotagliflozin Chemical Structure

CAS No. : 1018899-04-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.

IC50 & Target

SGLT1/2

In Vitro

LX4211 enhanced urinary glucose excretion by inhibiting SGLT2-mediated renal glucose reabsorption; markedly and significantly improved multiple measures of glycemic control, including fasting plasma glucose, oral glucose tolerance, and HbA(1c); and significantly lowered serum triglycerides. LX4211 also mediated trends for lower weight, lower blood pressure, and higher glucagon-like peptide-1 levels. In a follow-up single-dose study in 12 patients with T2DM, LX4211 (300 mg) significantly increased glucagon-like peptide-1 and peptide YY levels relative to pretreatment values, probably by delaying SGLT1-mediated intestinal glucose absorption [1]. LX4211-treated mice and SGLT1-/- mice also had increased GLP-1 AUC values, decreased glucose-dependent insulinotropic polypeptide (GIP) AUC values, and decreased blood glucose excursions during the 6 hours after a challenge with oral glucose alone [2].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (235.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3533 mL 11.7664 mL 23.5327 mL
5 mM 0.4707 mL 2.3533 mL 4.7065 mL
10 mM 0.2353 mL 1.1766 mL 2.3533 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

424.94

Formula

C₂₁H₂₅ClO₅S

CAS No.

1018899-04-1

SMILES

ClC(C=CC([[email protected]@H]1O[[email protected]](SC)[[email protected]@H](O)[[email protected]](O)[[email protected]]1O)=C2)=C2CC3=CC=C(OCC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.99%

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Product Name:
Sotagliflozin
Cat. No.:
HY-15516
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Sotagliflozin

Cat. No.: HY-15516