LYN-1604 hydrochloride
Based on 7 publication(s) in Google Scholar
LYN-1604 hydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).
For research use only. We do not sell to patients.
- CAS No.: 2216753-86-3
- Formula: C33H44Cl3N3O2
- Molecular Weight:621.08
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LYN-1604 hydrochloride
More- Nat Aging. 2026 May 14. [Abstract]
- J Transl Med. 2025 Oct 21;23(1):1144. [Abstract]
- Antioxidants (Basel). 2025 Nov 19;14(11):1381. [Abstract]
- Med Oncol. 2026 Mar 3;43(4):163. [Abstract]
- Cell Signal. 2024 Jun:118:111136. [Abstract]
- Biochem J. 2019 Mar 12;476(5):875-887. [Abstract]
- Oxid Med Cell Longev. 2021 Nov 15:2021:2896674. [Abstract]
Customer Validation & Images
-
WB
-
IF
Biological Activity
|
ULK1 18.94 nM (EC50) |
LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 μM against MDA-MB-231 cells) [1].
LYN-1604 binds to wild-type ULK1 with a binding affinity in the nanomole range (KD=291.4 nM) [1].
LYN-1604 (0.5, 1.0 and 2.0 μM) induces cell death via the ULK complex in MDA-MB-231 cells[1].
LYN-1604 (0.5-2 μM, 24 hours) induces remarkable up-regulation of Beclin-1 and degradation of p62, as well as transformation of LC3-I to LC3-II in MDA-MB-231 cells[1].
LYN-1604 induces ATG5-dependent autophagy via the ULK complex[1].
LYN-1604 can also increase cleavage of caspase3 and induce apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 cells
-
Concentration:0.5, 1.0 and 2.0 μM
-
Incubation Time:
-
Result:Induced cell death. Autophagy ratio was increased in a dose-dependent manner.
-
Cell Line:MDA-MB-231 cells
-
Concentration:0, 0.5, 1, and 2 μM
-
Incubation Time:24 hours
-
Result:Induced remarkable up-regulation of Beclin-1 and degradation of p62, as well as transformation of LC3-I to LC3-II.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:24 female nude mice (BALB/c, 6-8 weeks, 20-22 g)[1]
-
Dosage:Low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg
-
Administration:Intragastric administration; once a day for 14 days
-
Result:Significantly inhibited the growth of xenograft MDA-MB-231 cells. The body weights of mice were stable. By the end of the experiment, the liver and spleen weight indexes of mice were slightly increased in parts of the groups, while the kidney weight index was not affected in all dose groups.
Chemical Information
-
CAS No. 2216753-86-3
-
Appearance Solid
-
Molecular Weight 621.08
-
Formula C33H44Cl3N3O2
-
Color White to off-white
-
SMILES
ClC1=CC=C(C(CN2CCN(C(CN(CC(C)C)CC(C)C)=O)CC2)OCC3=CC=C(C=CC=C4)C4=C3)C(Cl)=C1.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
-
Journal Impact Factor
-
Most Recent
-
Nat Aging
2026 May 14. PMID: 42135576 -
J Transl Med
Pbk positively regulates myoblast differentiation and muscle regeneration via enhancing AMPK/ULK1 mediated myogenic autophagy. [Abstract]2025 Oct 21;23(1):1144. PMID: 41121382
LYN-1604 hydrochloride purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Oct 21;23(1):1144. [Abstract]
C2C12 cells treated with or without HI-TOPK-032 (2 μM) and LYN-1604 (2 μM) were induced to differentiation for 3 days. After that, cells were harvested and subjected to western blot to detect and quantify the protein levels of MyHC and autophagy related genes.
LYN-1604 hydrochloride purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Oct 21;23(1):1144. [Abstract]
C2C12 cells treated with or without HI-TOPK-032 (2 μM) and LYN-1604 (2 μM) were induced to differentiation for 3 days. Then cells were fixed and stained for MyHC (green) and DAPI (blue) to detect and quantify the differentiation index and fusion index of differentiating C2C12 cells.
-
Antioxidants (Basel)
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline. [Abstract]2025 Nov 19;14(11):1381. PMID: 41300537 -
Med Oncol
ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer. [Abstract]2026 Mar 3;43(4):163. PMID: 41774346 -
Cell Signal
microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression. [Abstract]2024 Jun:118:111136. PMID: 38471617 -
Biochem J
Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). [Abstract]2019 Mar 12;476(5):875-887. PMID: 30782972 -
Oxid Med Cell Longev
ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3. [Abstract]2021 Nov 15:2021:2896674. PMID: 34820053
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LYN-1604 hydrochloride Related Classifications
HY-101923A Related Classifications
Powered by Bioz