2. Autophagy Apoptosis
  3. ULK Autophagy Apoptosis
  4. LYN-1604

LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).

For research use only. We do not sell to patients.

CAS No. : 2088939-99-3

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Oil
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of LYN-1604:

LYN-1604 Related Antibodies

Top Publications Citing Use of Products

    LYN-1604 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Oct 21;23(1):1144.  [Abstract]

    C2C12 cells treated with or without HI-TOPK-032 (2 μM) and LYN-1604 (2 μM) were induced to differentiation for 3 days. After that, cells were harvested and subjected to western blot to detect and quantify the protein levels of MyHC and autophagy related genes.

    LYN-1604 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Oct 21;23(1):1144.  [Abstract]

    C2C12 cells treated with or without HI-TOPK-032 (2 μM) and LYN-1604 (2 μM) were induced to differentiation for 3 days. Then cells were fixed and stained for MyHC (green) and DAPI (blue) to detect and quantify the differentiation index and fusion index of differentiating C2C12 cells.

    View All ULK Isoform Specific Products:

    View All Isoforms
    ULK1 ULK2

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC)[1].

    IC50 & Target[1]

    ULK1

    18.94 nM (EC50)

    Cellular Effect
    Cell Line Type Value Description References
    MDA-MB-231 IC50
    1.66 μM
    Compound: 8; LYN-1604
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells by MTT assay
    		[PMID: 29509411]
    MDA-MB-231 IC50
    1.66 μM
    Compound: 12; LYN-1604
    Antiproliferative activity against human MDA-MB-231 cells assessed reduction in cell viability incubated for 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed reduction in cell viability incubated for 24 hrs by MTT assay
    		[PMID: 37595546]
    MDA-MB-231 IC50
    1.66 μM
    Compound: LYN-1604
    Antiproliferative activity against human MDA-MB-231 cells
    Antiproliferative activity against human MDA-MB-231 cells
    		[PMID: 38432059]
    In Vitro

    LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 μM against MDA-MB-231 cells) [1].
    LYN-1604 binds to wild-type ULK1 with a binding affinity in the nanomole range (KD=291.4 nM) [1].
    LYN-1604 (0.5, 1.0 and 2.0 μM) induces cell death via the ULK complex in MDA-MB-231 cells[1].
    LYN-1604 (0.5-2 μM, 24 hours) induces remarkable up-regulation of Beclin-1 and degradation of p62, as well as transformation of LC3-I to LC3-II in MDA-MB-231 cells[1].
    LYN-1604 induces ATG5-dependent autophagy via the ULK complex[1].
    LYN-1604 can also increase cleavage of caspase3 and induce apoptosis[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    LYN-1604 Related Antibodies

    Cell Viability Assay[1]

    Cell Line: MDA-MB-231 cells
    Concentration: 0.5, 1.0 and 2.0 μM
    Incubation Time:
    Result: Induced cell death. Autophagy ratio was increased in a dose-dependent manner.

    Western Blot Analysis[1]

    Cell Line: MDA-MB-231 cells
    Concentration: 0, 0.5, 1, and 2 μM
    Incubation Time: 24 hours
    Result: Induced remarkable up-regulation of Beclin-1 and degradation of p62, as well as transformation of LC3-I to LC3-II.
    In Vivo

    LYN-1604 (low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg; intragastric administration once a day for 14 days) inhibits the growth of xenograft TNBC by targeting ULK1-modulated cell death[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 24 female nude mice (BALB/c, 6-8 weeks, 20-22 g)[1]
    Dosage: Low dose, 25 mg/kg; median dose, 50 mg/kg; high dose, 100 mg/kg
    Administration: Intragastric administration; once a day for 14 days
    Result: Significantly inhibited the growth of xenograft MDA-MB-231 cells. The body weights of mice were stable. By the end of the experiment, the liver and spleen weight indexes of mice were slightly increased in parts of the groups, while the kidney weight index was not affected in all dose groups.
    Molecular Weight

    584.62

    Formula

    C33H43Cl2N3O2
    CAS No.
    Appearance

    Oil

    Color

    Colorless to light yellow

    SMILES

    ClC1=CC=C(C(CN2CCN(C(CN(CC(C)C)CC(C)C)=O)CC2)OCC3=CC=C(C=CC=C4)C4=C3)C(Cl)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (171.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7105 mL 8.5526 mL 17.1051 mL
    5 mM 0.3421 mL 1.7105 mL 3.4210 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7105 mL 8.5526 mL 17.1051 mL 42.7628 mL
    5 mM 0.3421 mL 1.7105 mL 3.4210 mL 8.5526 mL
    10 mM 0.1711 mL 0.8553 mL 1.7105 mL 4.2763 mL
    15 mM 0.1140 mL 0.5702 mL 1.1403 mL 2.8509 mL
    20 mM 0.0855 mL 0.4276 mL 0.8553 mL 2.1381 mL
    25 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7105 mL
    30 mM 0.0570 mL 0.2851 mL 0.5702 mL 1.4254 mL
    40 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0691 mL
    50 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.8553 mL
    60 mM 0.0285 mL 0.1425 mL 0.2851 mL 0.7127 mL
    80 mM 0.0214 mL 0.1069 mL 0.2138 mL 0.5345 mL
    100 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.4276 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    LYN-1604 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    LYN-16042088939-99-3LYN1604LYN 1604ULKAutophagyApoptosisUnc-51 like kinaseactivatorULK1anti-tumorautophagytriplenegativebreastcancerTNBCInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    LYN-1604
    Cat. No.:
    HY-101923
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.