Maxacalcitol (Synonyms: 22-Oxacalcitriol)

Name: Maxacalcitol
Brand: MedChemExpress
SKU: HY-32339
Rating: 5.0 (4 reviews)

製品番号: HY-32339 純度: 99.08%: Data Sheet SDS COA 取扱説明書
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Maxacalcitol (22-Oxacalcitriol), a vitamin D3 (HY-15398) analog, is an orally active VDR agonist. Maxacalcitol has a limited calcemic effect. Maxacalcitol has the potential for psoriasis and hyperparathyroidism research.

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Maxacalcitol 構造式

CAS 番号 : 103909-75-7

容量	価格（税別）	在庫状況	数量
1 mg	$122	在庫あり	Estimated Time of Arrival: December 31
5 mg	$440	在庫あり	Estimated Time of Arrival: December 31
10 mg	$680	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1350	在庫あり	Estimated Time of Arrival: December 31
50 mg	$2160	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Other Forms of Maxacalcitol:

Maxacalcitol-d₆ 在庫あり

顧客検証

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•関連小分子:

•関連タンパク質:

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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	EC₅₀	144.5 nM Compound: 22-oxa-1,25(OH)2D3	Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay	[PMID: 27070779]
Caco-2	EC₅₀	40.8 nM Compound: 22-oxa-1,25(OH)2D3	Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assay Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assay	[PMID: 26367019]
HaCaT	EC₅₀	159.7 nM Compound: 22-oxa-1,25(OH)2D3	Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay	[PMID: 27070779]
HaCaT	EC₅₀	37.9 nM Compound: 22-oxa-1,25(OH)2D3	Transactivation of VDR in human HaCaT cells after 24 hrs by luciferase reporter gene assay Transactivation of VDR in human HaCaT cells after 24 hrs by luciferase reporter gene assay	[PMID: 26367019]
Jurkat	EC₅₀	0.855 nM Compound: 22-oxa-1,25(OH)2D3	Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after 24 hrs by luciferase transcriptional reporter assay	[PMID: 27070779]
Keratinocyte	IC₅₀	22.6 nM Compound: 2, maxacalcitol	Antiproliferative activity against human keratinocyte assessed as inhibition of [3H]TdR uptake Antiproliferative activity against human keratinocyte assessed as inhibition of [3H]TdR uptake	[PMID: 16630723]

体外実験

Maxacalcitol (22-Oxacalcitriol; 100 nM; for 24 h) markedly increases the expression of LL-37 mRNA in Ca9-22 cells and modestly but significantly increases in HSC-2, HSC-3, and HSC-4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	Human gingival/oral epithelial cells
Concentration:	100 nM
Incubation Time:	24 h
Result:	Markedly increased the expression of LL-37 mRNA 77-fold in human gingival epithelial Ca9-22 cells and modestly but significantly increased in human oral epithelial HSC-2, HSC-3, and HSC-4 cells.

体内実験

Maxacalcitol (22-Oxacalcitriol; oral gavage; 15 µg/kg/day; 14 days) followed by GSK 269962 at a single dose of 10 mg/kg, leads to a statistically significant reduction of intercontraction interval and bladder compliance, and an increase in DO index, without any effect on ANVC, FNVC, and VTNVC^[2].
Maxacalcitol in a dose of 30 but not 15 µg/kg/day induced reduction in detrusor overactivity (DO) index, non-voiding contractions frequency (FNVC), and amplitude (ANVC), while increasing volume threshold to elicit non-voiding contractions (VTNVC)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Wistar rats (weighting 200-225 g)^[2]
Dosage:	15 µg/kg
Administration:	Oral gavage; daily; 14 days
Result:	Followed by GSK 269962 at a single dose of 10 mg/kg, led to a statistically significant reduction of intercontraction interval and bladder compliance, and an increase in DO index, without any effect on ANVC, FNVC, and VTNVC.

臨床実験

分子量

418.61

分子式

C₂₆H₄₂O₄

CAS 番号

103909-75-7

Appearance

Solid

Color

White to off-white

SMILES

C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](OCCC(C)(O)C)C)CCC/2)[H])O)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (119.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3889 mL	11.9443 mL	23.8886 mL
5 mM	0.4778 mL	2.3889 mL	4.7777 mL
10 mM	0.2389 mL	1.1944 mL	2.3889 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.67 mg/mL (3.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.67 mg/mL (3.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.67 mg/mL (3.99 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*The compound is unstable in solutions, freshly prepared is recommended.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.71%

Select Batch:

データシート (279 KB) SDS (480 KB)

COA (252 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Hiroyuki Tada, et al. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res. 2016;37(3):199-205. [Content Brief]

[2]. Andrzej Wróbel, et al. The Influence of Maxacalcitol, Vitamin D3 Analog, on Detrusor Overactivity in Conscious Rats. Urology. 2016 Jul:93:224.e7-224.e15. [Content Brief]

[3]. Masaru Karakawa, et al. Effects of maxacalcitol ointment on skin lesions in patients with psoriasis receiving treatment with adalimumab. J Dermatol. 2016 Nov;43(11):1354-1357. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3889 mL	11.9443 mL	23.8886 mL	59.7215 mL
	5 mM	0.4778 mL	2.3889 mL	4.7777 mL	11.9443 mL
	10 mM	0.2389 mL	1.1944 mL	2.3889 mL	5.9721 mL
	15 mM	0.1593 mL	0.7963 mL	1.5926 mL	3.9814 mL
	20 mM	0.1194 mL	0.5972 mL	1.1944 mL	2.9861 mL
	25 mM	0.0956 mL	0.4778 mL	0.9555 mL	2.3889 mL
	30 mM	0.0796 mL	0.3981 mL	0.7963 mL	1.9907 mL
	40 mM	0.0597 mL	0.2986 mL	0.5972 mL	1.4930 mL
	50 mM	0.0478 mL	0.2389 mL	0.4778 mL	1.1944 mL
	60 mM	0.0398 mL	0.1991 mL	0.3981 mL	0.9954 mL
	80 mM	0.0299 mL	0.1493 mL	0.2986 mL	0.7465 mL
	100 mM	0.0239 mL	0.1194 mL	0.2389 mL	0.5972 mL

Maxacalcitol Related Classifications

Metabolic Disease Inflammation/Immunology Endocrinology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maxacalcitol103909-75-722-OxacalcitriolVD/VDRVitamin DVitamin D receptorCalcemicpsoriasishyperparathyroidismInhibitorinhibitorinhibit

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Maxacalcitol (Synonyms: 22-Oxacalcitriol)

カスタマーレビュー

Other Forms of Maxacalcitol:

Maxacalcitol 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Maxacalcitol 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Maxacalcitol Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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