1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
  3. NGP555

NGP555 

Cat. No.: HY-108714
Handling Instructions

NGP555 is a γ-secretase modulator.

For research use only. We do not sell to patients.

NGP555 Chemical Structure

NGP555 Chemical Structure

CAS No. : 1304630-27-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 264 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 410 In-stock
Estimated Time of Arrival: December 31
25 mg USD 820 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

NGP555 is a γ-secretase modulator.

IC50 & Target

γ-secretase[1]

In Vitro

NGP555 potently lowers Aβ42 in cell cultures (9 nM) while increasing shorter forms of Aβ[1].

In Vivo

NGP555 significantly lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post dose, panel B shows that reduction of Aβ cerebrospinal fluid (CSF) levels is significant at 3.75 mg/kg of NGP555 and above, and panel C shows an increase in Aβ38 levels at 15 mg/kg of NGP555 and above. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above (panel D). NGP555-treated Tg mice show a significant protection from decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 also shows good oral bioavailability and is brain-penetrant with a brain:plasma ratio of ~0.93 in mice[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 42.9 mg/mL (105.53 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4599 mL 12.2995 mL 24.5990 mL
5 mM 0.4920 mL 2.4599 mL 4.9198 mL
10 mM 0.2460 mL 1.2300 mL 2.4599 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

SH-SY5Y-APP cells, Tg2576 mixed brain cultures, or C57 mixed brain cultures are treated with various concentrations of NGP555 in triplicate wells, for 18 hours. Media is collected and analyzed for Aβ peptides using triplex ELISA (Aβ38 and Aβ42)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

For CSF studies, Normal Sprague-Dawley male rats (250 to 300 g) are administered NGP555 in 80% PEG orally or vehicle only, n=10/group. Rats are dosed once-daily for a single-dose or 14 days of dosing. After the final dose, cerebrospinal fluid (CSF) samples are either collected at varying time points or a single time point post-last dose. Rats are deeply anesthetized with isoflurane, and CSF is collected from the cisterna magna. Samples are tested for Aβ level. For Y-maze study, transgenic mice (Tg2576 line expressing the APP-Swe mutation) and non-transgenic age-matched littermates (n=a minimum of 12/group) are treated with vehicle, NGP555 (25 mg/kg) once-daily for 30 consecutive days (starting at 5 months of age). At 6 months, mice are assessed on the Y-maze behavior test[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

406.52

Formula

C₂₃H₂₃FN₄S

CAS No.

1304630-27-0

SMILES

CC1=CN(C2=CC=C(C3=CSC(NC4=CC(CC)=C(C)C=C4C)=N3)C=C2F)C=N1

Shipping

Room temperature in continental US; may vary elsewhere

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NGP555
Cat. No.:
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NGP555

Cat. No.: HY-108714